公开(公告)号：US20240000892A1

公开(公告)日：2024-01-04

申请号：US18038140

申请日：2021-11-26

Applicant: Ospedale San Raffaele S.r.l.

Inventor： Luca Guidotti ,  Matteo Iannacone

IPC: A61K38/20 ,  A61K45/06 ,  A61P37/04

CPC classification number: A61K38/2013 ,  A61K38/2046 ,  A61K38/2086 ,  A61K45/06 ,  A61P37/04

Abstract: An agent that increases the number ofKupffer cells in a subject, or a nucleotide sequence encoding therefor, for use in a method of therapy by increasing liver immune response.

公开(公告)号：US20220251161A1

公开(公告)日：2022-08-11

申请号：US17614268

申请日：2020-05-28

Applicant: Ospedale San Raffaele S.R.L. ,  Fondazione Telethon

Inventor： Luigi Naldini ,  Alessio Cantore ,  Matteo Iannacone ,  Luca Guidotti ,  Renato Ostuni

IPC: C07K14/55 ,  C12N15/86 ,  C12N15/113 ,  A61K35/17 ,  A61K38/17 ,  A61P31/20

Abstract: An interleukin which binds to IL-2 receptor (IL-2R), or a nucleotide sequence encoding therefor, wherein the interleukin or nucleotide sequence is adapted to be targeted to the liver.