公开(公告)号：US20130072683A1

公开(公告)日：2013-03-21

申请号：US13677727

申请日：2012-11-15

申请人： Otsuka Pharmaceutical Co., Ltd.

发明人： Hidetsugu Tsubouchi ,  Yoshikazu Haraguchi ,  Satoshi Hayakawa ,  Naoto Utsumi ,  Shinichi Taira ,  Yoshihisa Tanada ,  Nobuhisa Fujita ,  Koichi Shinhama ,  Kimiyoshi Annaka ,  Takuya Furuta

IPC分类号： C07D405/12

CPC分类号： C07D405/12 ,  C07D303/18 ,  C07D498/04

摘要： The present invention provides a novel intermediate for manufacturing a 2,3-dihydroimidazo[2,1-b]oxazole compound with a high yield and a high purity, and a manufacturing method of the intermediate. The present invention provides an epoxy compound represented by the general formula (2): wherein, R1 represents a hydrogen or a lower alkyl group; and R2 represents a piperidyl group represented by the general formula (A1): (wherein, R3 represents a phenoxy group having a halogen-substituted lower alkoxy group substituted on a phenyl group, and the like) and the like; and n represents an integer of 1 to 6, a manufacturing method of the epoxy compound, and a manufacturing method of an oxazole compound using the epoxy method.

摘要翻译： 本发明提供了一种制备具有高产率和高纯度的2,3-二氢咪唑并[2,1-b]恶唑化合物的新型中间体及其制备方法。 本发明提供由通式（2）表示的环氧化合物：其中，R1表示氢或低级烷基; R 2表示由通式（A1）表示的哌啶基：（其中，R3表示在苯基取代的卤素取代的低级烷氧基的苯氧基等）等。 n表示1〜6的整数，环氧化合物的制造方法和使用环氧方法的恶唑化合物的制造方法。

公开(公告)号：US08552188B2

公开(公告)日：2013-10-08

申请号：US13677727

申请日：2012-11-15

申请人： Otsuka Pharmaceutical Co., Ltd.

发明人： Hidetsugu Tsubouchi ,  Yoshikazu Haraguchi ,  Satoshi Hayakawa ,  Naoto Utsumi ,  Shinichi Taira ,  Yoshihisa Tanada ,  Nobuhisa Fujita ,  Koichi Shinhama ,  Kimiyoshi Annaka ,  Takuya Furuta

IPC分类号： C07D405/12

CPC分类号： C07D405/12 ,  C07D303/18 ,  C07D498/04

摘要： The present invention provides a novel intermediate for manufacturing a 2,3-dihydroimidazo[2,1-b]oxazole compound with a high yield and a high purity, and a manufacturing method of the intermediate. The present invention provides an epoxy compound represented by the general formula (2): wherein, R1 represents a hydrogen or a lower alkyl group; and R2 represents a piperidyl group represented by the general formula (A1): (wherein, R3 represents a phenoxy group having a halogen-substituted lower alkoxy group substituted on a phenyl group, and the like) and the like; and n represents an integer of 1 to 6, a manufacturing method of the epoxy compound, and a manufacturing method of an oxazole compound using the epoxy method.

摘要翻译： 本发明提供了一种制备具有高产率和高纯度的2,3-二氢咪唑并[2,1-b]恶唑化合物的新型中间体及其制备方法。 本发明提供由通式（2）表示的环氧化合物：其中，R1表示氢或低级烷基; R 2表示由通式（A1）表示的哌啶基：（其中，R3表示在苯基取代的卤素取代的低级烷氧基的苯氧基等）等。 n表示1〜6的整数，环氧化合物的制造方法和使用环氧方法的恶唑化合物的制造方法。