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公开(公告)号：US08025878B2
公开(公告)日：2011-09-27
申请号：US12294207
申请日：2007-03-23
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： G01N33/6896 , A61K2039/505 , C07K16/18 , C07K16/465 , C07K2317/24 , C07K2317/565 , G01N2333/4709 , G01N2800/2814 , G01N2800/387
摘要： The present invention pertains to the prevention, treatment and diagnosis of neurodegenerative diseases, in particular Alzheimer's disease, and other similar disease. More specifically to high affinity antibodies selective for amyloid beta protein (Aβ) in its protofibril conformation and of IgG class and IgG1 or IgG4 subclass or combinations thereof or mutations thereof, retaining high Fc receptor binding and low C1(C1q) binding, effective in clearance of Aβ protofibrils and with reduce risk of inflammation.
摘要翻译： 本发明涉及神经变性疾病，特别是阿尔茨海默氏病和其他类似疾病的预防，治疗和诊断。 更具体地，涉及其原始原纤维构象中的淀粉样蛋白β蛋白（A＆bgr）和IgG类和IgG1或IgG4亚类或其组合或其突变选择性的高亲和力抗体，保持高Fc受体结合和低C1（C1q）结合，有效地 清关A＆BGR 原纤维，并减少炎症的风险。
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公开(公告)号：US09034334B2
公开(公告)日：2015-05-19
申请号：US13219012
申请日：2011-08-26
IPC分类号： A61K39/00 , A61K39/395 , G01N33/68 , C07K16/18 , C07K16/46
CPC分类号： G01N33/6896 , A61K2039/505 , C07K16/18 , C07K16/465 , C07K2317/24 , C07K2317/565 , G01N2333/4709 , G01N2800/2814 , G01N2800/387
摘要： The invention relates to an isolated antibody, or fragment thereof, having high affinity for human Aβ protofibrils. The invention further relates to compositions that include the antibody, or a fragment thereof, and a pharmaceutically acceptable buffer. The invention further relates to a method of preventing or treating Alzheimer's disease, which includes the step of administering to a patient having or suspected of having Alzheimer's disease such an antibody, or fragment thereof or a composition that includes the antibody or a fragment thereof.
摘要翻译： 本发明涉及对人A＆bgr具有高亲和力的分离的抗体或其片段; 原纤维。 本发明还涉及包含抗体或其片段和药学上可接受的缓冲液的组合物。 本发明还涉及一种预防或治疗阿尔茨海默病的方法，其包括对具有或疑似患有阿尔茨海默病的患者或其片段或包含该抗体或其片段的组合物的患者给药的步骤。
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公开(公告)号：US20090258009A1
公开(公告)日：2009-10-15
申请号：US12294207
申请日：2007-03-23
IPC分类号： A61K39/395 , C07K16/18 , A61P25/28 , A61P25/18 , A61P25/00 , G01N33/566
CPC分类号： G01N33/6896 , A61K2039/505 , C07K16/18 , C07K16/465 , C07K2317/24 , C07K2317/565 , G01N2333/4709 , G01N2800/2814 , G01N2800/387
摘要： The present invention pertains to the prevention, treatment and diagnosis of neurodegenerative diseases, in particular Alzheimer's disease, and other similar disease. More specifically to high affinity antibodies selective for amyloid beta protein (Aβ) in its protofibril conformation and of IgG class and IgG1 or IgG4 subclass or combinations thereof or mutations thereof, retaining high Fc receptor binding and low C1(CIq) binding, effective in clearance of Aβ protofibrils and with reduce risk of inflammation.
摘要翻译： 本发明涉及神经变性疾病，特别是阿尔茨海默氏病和其他类似疾病的预防，治疗和诊断。 更具体地，涉及其原始原纤维构象中的淀粉样蛋白β蛋白（Abeta）和IgG类和IgG1或IgG4亚类或其组合或其突变选择性的高亲和力抗体，保留高Fc受体结合和低C1（C1q）结合，有效清除 的Abeta原纤维，并减少炎症的风险。
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