DIAGNOSIS OF SYSTEMIC DISEASES
    1.
    发明申请
    DIAGNOSIS OF SYSTEMIC DISEASES 审中-公开
    系统疾病诊断

    公开(公告)号:US20110136140A1

    公开(公告)日:2011-06-09

    申请号:US13055320

    申请日:2009-07-21

    CPC classification number: G01N33/564 C12Q1/533 G01N2333/99 G01N2800/104

    Abstract: It has been found that the pattern of recognized topo I epitopes is different between dcSSc, IcSSc and SLE patients. Fragment F4 (amino acid (AA) 450-600) was recognized by all patients tested. Fragment F1 (AA 5-30) and Fragment F8 (AA 350-400) represent characteristic epitopes for dcSSc and SLE, respectively. The invention relates to diagnostic uses and methods as well as kits for use in diagnosis.

    Abstract translation: 已经发现,识别的topo I表位的图案在dcSSc,IcSSc和SLE患者之间是不同的。 片段F4(氨基酸(AA)450-600)被所有测试的患者认可。 片段F1(AA 5-30)和片段F8(AA350-400)分别表示dcSSc和SLE的特征表位。 本发明涉及诊断用途和方法以及用于诊断的试剂盒。

    ARTICULAR CARTILAGE, DEVICE AND METHOD FOR REPAIRING CARTILAGE DEFECTS
    2.
    发明申请
    ARTICULAR CARTILAGE, DEVICE AND METHOD FOR REPAIRING CARTILAGE DEFECTS 审中-公开
    用于修复牙槽骨缺损的装置,装置和方法

    公开(公告)号:US20100211173A1

    公开(公告)日:2010-08-19

    申请号:US12674772

    申请日:2008-08-01

    Abstract: The articular cartilage according to the invention is made of pure cartilage and is provided with incisions (12) on the surface facing the bone. The cartilage cells are preferably seeded on the surface provided with incisions (12). The method for producing the articular cartilage comprises the step of collecting cartilage from joints, wherein pure cartilage is collected without bone, and incisions are made on the surface of the cartilage intended to face the bone. It is preferably fresh frozen until use. The device for harvesting articular cartilage, comprises handle and cutting blade, wherein the cutting blade (4) is curvilinear and is provided with spacer elements (5), meanwhile the device for producing incisions in articular cartilages comprises handle (2) and a bridge (3) connected to said handle (2) and being provided with one or more cutting blade(s) (4). During the method for applying the articular cartilage the articular cartilage is fixed by thin surgical yarn stitches, by fibrin glue or by small anchors (FIG. 8).

    Abstract translation: 根据本发明的关节软骨由纯软骨制成,并且在面向骨的表面上设有切口(12)。 将软骨细胞优选接种在具有切口(12)的表面上。 用于生产关节软骨的方法包括从关节收集软骨的步骤,其中在没有骨的情况下收集纯软骨,并且在旨在面向骨的软骨的表面上形成切口。 它最好是新鲜冷冻直到使用。 用于收获关节软骨的装置包括手柄和切割刀片,其中切割刀片(4)是曲线的,并且设置有间隔元件(5),同时用于在关节软骨中产生切口的装置包括手柄(2)和桥 3)连接到所述手柄(2)并且设置有一个或多个切割刀片(4)。 在用于施用关节软骨的方法中,关节软骨通过细长的手术纱线针迹,纤维蛋白胶或小锚定固定(图8)。

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