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    MODIFIED MITOCHONDRIA AND USE THEREOF
    1.
    发明申请
    MODIFIED MITOCHONDRIA AND USE THEREOF 有权

    公开(公告)号：US20210238249A1

    公开(公告)日：2021-08-05

    申请号：US17049301

    申请日：2019-04-25

    申请人： PAEAN BIOTECHNOLOGY INC.

    发明人： Kyuboem HAN ,  Chun-Hyung KIM ,  Yu Jin KIM ,  Shin-Hye YU ,  Nayoung KIM ,  Mi Jin KIM ,  Yong-Soo CHOI ,  Seo Eun LEE

    IPC分类号： C07K14/705 ,  A61P35/00 ,  C07K14/47 ,  C12N9/64 ,  C12N9/16 ,  C07K16/32 ,  C07K16/28 ,  A61P35/04

    摘要： Mitochondria modified by a targeting protein, according to one embodiment of the present invention, can be effectively delivered to a target. In addition, when a protein of interest bound to the modified mitochondria is delivered into a cell, various activities can be exhibited. The modified mitochondria can effectively cause cancer tissue death, and thus can also be used as an anticancer agent. Furthermore, various activities are exhibited according to a protein of interest loaded on modified mitochondria, and thus the modified mitochondria can be applied in the treatment of various diseases. Additionally, a fusion protein comprising a protein of interest and a fusion protein comprising a targeting protein, according to one embodiment of the present invention, can be used in order to modify mitochondria. Moreover, mitochondria modified with the fusion proteins exhibits various effects in a target cell.