公开(公告)号：US09278953B2

公开(公告)日：2016-03-08

申请号：US14506752

申请日：2014-10-06

Applicant: Pfizer Inc.

Inventor： Kevin Barry Bahnck ,  David James Edmonds ,  Kentaro Futatsugi ,  Esther Cheng Yin Lee ,  Alan Martin Mathiowetz ,  Elnaz Menhaji-Klotz ,  Robert Vernon Stanton

IPC: C07D213/63 ,  A61K31/44 ,  C07D401/14

CPC classification number: C07D401/14

Abstract: Provided herein are antagonists of prostaglandin EP3 receptor, processes to make said antagonists, and methods comprising administering said antagonists to a mammal in need thereof.

Abstract translation: 本文提供前列腺素EP3受体的拮抗剂，制备所述拮抗剂的方法，以及包括向有需要的哺乳动物施用所述拮抗剂的方法。

公开(公告)号：US20240336572A1

公开(公告)日：2024-10-10

申请号：US18626467

申请日：2024-04-04

Applicant: Pfizer Inc.

Inventor： Samit Kumar Bhattacharya ,  Edward Lee Conn ,  David Christopher Ebner ,  Brian Stephen Gerstenberger ,  Chan Woo Huh ,  Daniel Wei-Shung Kung ,  Alan Martin Mathiowetz ,  Jessica Gloria Katherine O'Brien ,  Meihua Mike Tu ,  Kimberly O'Keefe Cameron ,  Dilinie Prasadhini Fernando ,  Kevin James Filipski ,  Esther Cheng Yin Lee ,  Sarah Jane Mear ,  Aaron Christopher Smith

IPC: C07D231/56 ,  A61K31/416

CPC classification number: C07D231/56 ,  A61K31/416

Abstract: The invention relates to substituted indazole propionic acid derivatives, pharmaceutically acceptable salts, tautomers, or pharmaceutically acceptable salts of the tautomers thereof that can activate adenosine 5′-monophosphate-activated protein kinase (AMPK). The invention further relates to pharmaceutical compositions comprising AMPK-activating substituted indazole propionic acid derivatives, pharmaceutically acceptable salts, tautomers, or pharmaceutically acceptable salts of the tautomers thereof and at least one pharmaceutically acceptable excipient, and methods of treating a condition comprising administering AMPK-activating substituted indazole propionic acid derivatives, pharmaceutically acceptable salts, tautomers, or pharmaceutically acceptable salts of the tautomers thereof.

公开(公告)号：US20150099782A1

公开(公告)日：2015-04-09

申请号：US14506752

申请日：2014-10-06

Applicant: PFIZER INC.

Inventor： Kevin Barry Bahnck ,  David James Edmonds ,  Kentaro Futatsugi ,  Esther Cheng Yin Lee ,  Alan Martin Mathiowetz ,  Elnaz Menhaji-Klotz ,  Robert Vernon Stanton

IPC: C07D401/14

CPC classification number: C07D401/14

Abstract: Provided herein are antagonists of prostaglandin EP3 receptor, processes to make said antagonists, and methods comprising administering said antagonists to a mammal in need thereof.

Abstract translation: 本文提供前列腺素EP3受体的拮抗剂，制备所述拮抗剂的方法，以及包括向有需要的哺乳动物施用所述拮抗剂的方法。