公开(公告)号：US11891373B2

公开(公告)日：2024-02-06

申请号：US17494938

申请日：2021-10-06

Applicant: PFIZER INC.

Inventor： Eric Christian Hansen ,  Christopher Scott Seadeek ,  Anil Mahadeo Rane

IPC: C07D401/04 ,  A61K31/4439

CPC classification number: C07D401/04 ,  A61K31/4439 ,  C07B2200/13

Abstract: This invention relates to a crystalline form of 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate, and to pharmaceutical compositions thereof, to intermediates and methods for the production and isolation of such crystalline forms and compositions, and to methods of using such crystalline forms and compositions in the treatment of abnormal cell growth in mammals, especially humans.

公开(公告)号：US20220024894A1

公开(公告)日：2022-01-27

申请号：US17494938

申请日：2021-10-06

Applicant: PFIZER INC.

Inventor： Eric Christian Hansen ,  Christopher Scott Seadeek ,  Anil Mahadeo Rane

IPC: C07D401/04 ,  A61K31/4439

Abstract: This invention relates to a crystalline form of 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate, and to pharmaceutical compositions thereof, to intermediates and methods for the production and isolation of such crystalline forms and compositions, and to methods of using such crystalline forms and compositions in the treatment of abnormal cell growth in mammals, especially humans.

公开(公告)号：US11891372B2

公开(公告)日：2024-02-06

申请号：US17494923

申请日：2021-10-06

Applicant: PFIZER INC.

Inventor： Christopher Scott Seadeek

IPC: C07D401/04 ,  A61K31/4439

CPC classification number: C07D401/04 ,  A61K31/4439 ,  C07B2200/13

Abstract: This invention relates to a crystalline form of 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate, and to pharmaceutical compositions thereof, to intermediates and methods for the production and isolation of such crystalline forms and compositions, and to methods of using such crystalline forms and compositions in the treatment of abnormal cell growth in mammals, especially humans.

公开(公告)号：US11168066B2

公开(公告)日：2021-11-09

申请号：US16521742

申请日：2019-07-25

Applicant: PFIZER INC.

Inventor： Christopher Scott Seadeek

IPC: A61K31/4439 ,  C07D401/04

Abstract: This invention relates to a crystalline form of 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate, and to pharmaceutical compositions thereof, to intermediates and methods for the production and isolation of such crystalline forms and compositions, and to methods of using such crystalline forms and compositions in the treatment of abnormal cell growth in mammals, especially humans.

公开(公告)号：US10414748B2

公开(公告)日：2019-09-17

申请号：US15567433

申请日：2016-04-13

Applicant: PFIZER INC.

Inventor： Christopher Scott Seadeek

IPC: C07D401/04

Abstract: This invention relates to a crystalline form of 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate, and to pharmaceutical compositions thereof, to intermediates and methods for the production and isolation of such crystalline forms and compositions, and to methods of using such crystalline forms and compositions in the treatment of abnormal cell growth in mammals, especially humans.

公开(公告)号：US20220024893A1

公开(公告)日：2022-01-27

申请号：US17494923

申请日：2021-10-06

Applicant: PFIZER INC.

Inventor： Eric Christian Hansen ,  Christopher Scott Seadeek

IPC: C07D401/04 ,  A61K31/4439

Abstract: This invention relates to a crystalline form of 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate, and to pharmaceutical compositions thereof, to intermediates and methods for the production and isolation of such crystalline forms and compositions, and to methods of using such crystalline forms and compositions in the treatment of abnormal cell growth in mammals, especially humans.

公开(公告)号：US20190382368A1

公开(公告)日：2019-12-19

申请号：US16521742

申请日：2019-07-25

Applicant: PFIZER INC.

Inventor： Eric Christian Hansen ,  Christopher Scott Seadeek

IPC: C07D401/04

Abstract: This invention relates to a crystalline form of 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate, and to pharmaceutical compositions thereof, to intermediates and methods for the production and isolation of such crystalline forms and compositions, and to methods of using such crystalline forms and compositions in the treatment of abnormal cell growth in mammals, especially humans.

公开(公告)号：US20180086731A1

公开(公告)日：2018-03-29

申请号：US15567433

申请日：2016-04-13

Applicant: PFIZER INC.

Inventor： Eric Christian Hansen ,  Christopher Scott Seadeek

IPC: C07D401/04

CPC classification number: C07D401/04 ,  C07B2200/13

Abstract: This invention relates to a crystalline form of 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate, and to pharmaceutical compositions thereof, to intermediates and methods for the production and isolation of such crystalline forms and compositions, and to methods of using such crystalline forms and compositions in the treatment of abnormal cell growth in mammals, especially humans.