公开(公告)号：US20160102074A1

公开(公告)日：2016-04-14

申请号：US14868933

申请日：2015-09-29

Applicant: PFIZER INC.

Inventor： Etzer Darout ,  Kim F. McClure ,  David Piotrowski ,  Brian Raymer

IPC: C07D401/14 ,  A61K45/06 ,  A61K31/4545

CPC classification number: C07D401/14 ,  A61K31/4545 ,  A61K45/06

Abstract: The present invention is directed at substituted amide compounds, pharmaceutical compositions containing such compounds and the use of such compounds to reduce plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases, in mammals, including humans.