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1.
公开(公告)号:US20170197939A1
公开(公告)日:2017-07-13
申请号:US15300440
申请日:2015-04-01
Applicant: PFIZER INC.
Inventor: Sharanjeet Kaur Bagal , Jingrong Jean Cui , Samantha Elizabeth Greasley , Elizabeth Ann Lunney , Indrawan James McAlpine , Asako Nagata , Sacha Ninkovic , Kiyoyuki Omoto , Sarah Elizabeth Skerratt , Robert Ian Storer , Joseph Scott Warmus
IPC: C07D401/14 , A61K31/4439 , C07D401/12
CPC classification number: C07D401/14 , A61K31/4439 , C07D401/12
Abstract: The present invention relates to compounds of Formula I and their prodrugs and pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine, in particular as TrkA antagonists.
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公开(公告)号:US09328096B2
公开(公告)日:2016-05-03
申请号:US14705272
申请日:2015-05-06
Applicant: PFIZER INC
Inventor: Sharanjeet Kaur Bagal , Jingrong Jean Cui , Samantha Elizabeth Greasley , Elizabeth Ann Lunney , Indrawan James McAlpine , Asako Nagata , Sacha Ninkovic , Kiyoyuki Omoto , Sarah Elizabeth Skerratt , Robert Ian Storer , Joseph Scott Warmus
IPC: A61P35/00 , C07D413/14 , A61P29/00 , C07D405/14 , A61K31/4439 , C07D401/12 , C07D401/14
CPC classification number: C07D401/14 , C07D401/12 , C07D405/14 , C07D413/14
Abstract: The present invention relates to compounds of Formula I and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine, in particular as TrkA antagonists.
Abstract translation: 本发明涉及式I化合物及其药学上可接受的盐,其中取代基如本文所述,及其在药物中的用途,特别是作为TrkA拮抗剂。
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