公开(公告)号：US20230059489A1

公开(公告)日：2023-02-23

申请号：US17849467

申请日：2022-06-24

Applicant: PFIZER INC.

Inventor： Danielle Elizabeth DETTLING ,  Yik Andy YEUNG ,  Kristian Todd POULSEN ,  Veena KRISHNAMOORTHY ,  Cesar Adolfo SOMMER

IPC: C07K16/46 ,  C07K16/28 ,  A61P35/02 ,  A61P35/00

Abstract: The present invention provides antibodies that specifically bind to FLT3 (Fms-Like Tyrosine Kinase 3). The invention further provides bispecific antibodies that bind to FLT3 and another antigen (e.g., CD3). The invention further relates to antibody encoding nucleic acids, and methods of obtaining such antibodies (monospecific and bispecific). The invention further relates to therapeutic methods for use of these antibodies for the treatment of FLT3-mediated pathologies, including cancer such as Acute Myeloid Leukemia (AML).

公开(公告)号：US20180346601A1

公开(公告)日：2018-12-06

申请号：US15993874

申请日：2018-05-31

Applicant: PFIZER INC.

Inventor： Danielle Elizabeth DETTLING ,  Yik Andy YEUNG ,  Kristian Todd POULSEN ,  Veena KRISHNAMOORTHY ,  Cesar Adolfo SOMMER

IPC: C07K16/46 ,  A61P35/00 ,  C07K16/28

CPC classification number: C07K16/2863 ,  A61K2039/505 ,  A61P35/02 ,  C07K16/2809 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/92

Abstract: The present invention provides antibodies that specifically bind to FLT3 (Fms-Like Tyrosine Kinase 3). The invention further provides bispecific antibodies that bind to FLT3 and another antigen (e.g., CD3). The invention further relates to antibody encoding nucleic acids, and methods of obtaining such antibodies (monospecific and bispecific). The invention further relates to therapeutic methods for use of these antibodies for the treatment of FLT3-mediated pathologies, including cancer such as Acute Myeloid Leukemia (AML).