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公开(公告)号:US20180021429A1
公开(公告)日:2018-01-25
申请号:US15550461
申请日:2016-02-16
发明人: Chie KUDO , Masayoshi TOYOURA , Akiko ISHIDA , Yuji SHOYA , Chihiro YAMAZAKI
IPC分类号: A61K39/395 , C07K16/18
摘要: The present invention provides an anti-FSTL1 antibody or a fragment or functional equivalent thereof, wherein the antibody recognizes an epitope in a region selected from the group consisting of amino acid positions 48 to 100, 148 to 162, 193 to 216, 205 to 228, and 272 to 289 of SEQ ID NO: 1 (amino acid sequence of human FSTL1). The present invention also provides a combination product of a FSTL1 suppressor and additional cancer treatment. It is understood that immune defect such as immunosuppression or immunodeficiency is effectively mitigated by the present invention.