公开(公告)号：US3632737A

公开(公告)日：1972-01-04

申请号：US3632737D

申请日：1968-12-26

申请人： PHARMACIA AB

发明人： INGELMAN BJORN G-A

IPC分类号： A61K49/04 ,  A61K27/08

CPC分类号： A61K49/0433

摘要： COMPOSITIONS WHICH COMPRISE AT LEAST ONE IODINE COMPOUND OF THE FORMULA:

1,3,5-TRI(I-),2-(R''-NH-),4-(HOOC-),6-((2,4,6-TRI(I-),

3-(R4-NH-),5-(HOOC-)PHENYL)-N(-R3)-A-N(-R2)-)BENZENE

WHEREIN R1-R4 ARE EACH LOWER ACYL HAVING NO MORE THAN 5 CARBON ATOMS AND WHEREIN A IS AN ALKYLENE GROUP SUBSTITUTED BY AT LEAST 1 SUBSTITUENT OF THE FORMULA -O-R, WHEREIN R IS EITHER HYDROGEN, OR A LOWER ALKYL OR ACYL HAVING NO MORE THAN 5 CARBON ATOMS, THE ALKYLENE GROUP CONTAINING 3-20 CARBON ATOMS, AND BEING OPTIONALLY BROKEN BY ONE OR MORE OXYGEN BRIDGES OR A PHYSIOLOGICALLY X-RAY CONTRAST COMPOSITIONS AND ARE ADMINSTERED TO THE BODY OF THE TEST OBJECT FOR THE X-RAY VISUALIZATION OF THE BODY CAVITIES.

公开(公告)号：US3632738A

公开(公告)日：1972-01-04

申请号：US3632738D

申请日：1968-12-26

申请人： PHARMACIA AB

发明人： INGELMAN BJORN G-A

IPC分类号： A61K49/04 ,  A61K27/08

CPC分类号： A61K49/0433

摘要： COMPOSITIONS WHICH COMPRISE AT LEAST ONE IODINE COMPOUND OF THE FORMULA:

1,3,5-TRI(I-),2-(Z-CO-),4-(HOOC-),6-((2,4,6-TRI(I-),

3-(Z''-CO-),5-(HOOC-)PHENYL)-N(-R''3)-A-N(-R3)-)BENZENE

WHEREIN Z AND Z'' ARE EACH EITHER AMINO GROUPS OF THE FORMULA

-NR1R2

WHEREIN R1 AND R2 ARE EACH HYDROGEN OR A LOWER ALKYL HAVING NO MORE THAN 5 CARBON ATOMS; OR Z AND Z'' ARE EACH AMINO GROUPS OF THE FORMULA

-N
WHEREIN R1 AND R2 ARE LINKED TOGETHER INTO A HETEROCYCLIC RING SYSTEM; AND R3 AND R''3 ARE EACH A LOWER ACYL HAVING NO MORE THAN 5 CARBON ATOMS; AND WHEREIN A IS AN ALKYLENE GROUP SUBSTITUTED BY AT LEAST ONE SUBSTITUENT OF THE FORMULA -O-R4, WHEREIN R4 IS EITHER HYDROGEN; LOWER ALKYL; OR LOWER ACYL HAVING NO MORE THAN 5 CARBON ATOMS, THE ALKYLENE GROUP CONTAINING 3-20 CARBON ATOMS, AND BEING OPTIONALLY BROKEN BY ONE OR MORE OXYGEN BRIDGES, OR A PHYSIOLOGICALLY ACCEPTABLE SALT THEREOF. SUCH COMPOSITIONS ARE USEFUL AS X-RAY CONTRAST COMPOSITIONS AND ARE ADMINISTERED TO THE BODY OF THE TEST OBJECT FOR THE X-RAY VISUALIZATION OF THE BODY CAVITY.

公开(公告)号：US3632736A

公开(公告)日：1972-01-04

申请号：US3632736D

申请日：1968-12-26

申请人： PHARMACIA AB

发明人： INGELMAN BJORN G-A

IPC分类号： A61K49/04 ,  A61K27/08

CPC分类号： A61K49/0433

摘要： COMPOSITIONS WHICH COMPRISE AT LEAST ONE IODINE COMPOUND OF THE FORMULA:

1,3,5-TRI(I-),2-(R1-N(-R2)-CH2-),4-(HOOC-),6-((2,4,6-

TRI(I-),3-(R1''-N(-R2'')-CH2-),5-(HOOC-)PHENYL)-N(-R3'')-

A-N(-R3)-)BENZENE

WHEREIN R1 AND R1'' ARE EACH HYDROGEN OR A LOWER ALKYL HAVING NO MORE THAN 5 CARBON ATOMS, R2; R2''; R3; AND R3'' ARE EACH LOWER ACYL HAVING NO MORE THAN 5 CARBON ATOMS, AND A IS AN ALKYLENE GROUP SUBSTITUTED BY 1 OR MORE SUBSTITUENTS OF THE FORMULA-O-R4, WHEREIN R4 IS HYDROGEN OR LOWER ALKYL OR ACYL HAVING NO MORE THAN 5 CARBON ATOMS; THE ALKYLENE GROUP CONTAINING 3 TO 20 CARBON ATOMS AND BEING OPTIONALLY BROKEN BY ONE OR MORE OXYGEN BRIDGES, OR A PHUSIOLOGICALLY ACCEPTABLE SALT THEREOF. SUCH COMPOSITIONS ARE USEFUL AS X-RAY CONTRAST COMPOSITIONS AND ARE ADMINISTERED TO THE BODY OF THE TEST OBJECT FOR THE X-RAY VISUALLIZATION OF THE BODY CAVITY.

公开(公告)号：US3574718A

公开(公告)日：1971-04-13

申请号：US3574718D

申请日：1967-12-11

申请人： PHARMACIA AB

发明人： BJORK LARS ,  ERIKSON UNO E ,  INGELMAN BJORN G-A ,  LINDBERG BERNT J

IPC分类号： A61K49/04 ,  C07C101/48 ,  C07C103/32

CPC分类号： A61K49/0452

摘要： IODINE COMPOUNDS OF THE FORMULA;

((2,4,6-TRI(I-),3-(HOOC-)PHENYL)-N(-R))2-A

WHEREIN R IS A LOWER ACYL GROUP HAVING NO MORE THAN 5 CARBON ATOMS AND WHEREIN A IS AN ALKYLENE GROUP SUBSTITUTED BY AT LEAST ONE SUBSTITUENT OF THE FORMULA -O-R1 WHEREIN R1 IS A HYDROGEN OR A LOWER ALKYL OR A LOWER ACYL GROUP HAVING NO MORE THAN 5 CARBON ATOMS, SAID ALKYLENE GROUP CONTAINING FROM 3 TO 15 INCLUSIVE CARBON ATOMS AND BEING OPTIONALLY BROKEN BY ONE OR MORE OXYGEN BRIDGES; OR PHYSIOLOGICALLY ACCEPTABLE SALTS THEREOF; AND THEIR METHOD OF PREPARATION ARE PROVIDED. THESE COMPOUNDS ARE ESPECIALLY USEFUL AS X-RAY CONTRAST AGENTS.

公开(公告)号：US3692824A

公开(公告)日：1972-09-19

申请号：US3692824D

申请日：1970-04-10

申请人： PHARMACIA AB

发明人： BJORK LARS ,  ERIKSON UNO E ,  INGELMAN BJORN G-A

IPC分类号： A61K49/04 ,  C07C103/32

CPC分类号： A61K49/0433

摘要： WHEREIN R1 is methyl or ethyl and R2 and R3 are each acetyl or propionyl and wherein A is an alkylene group substituted by at least one hydroxy group, said alkylene containing from three to 15 carbon atoms and being optionally broken by one or more oxygen bridges; or physiologically acceptable salts of said compounds.

Iodo compounds useful in the X-ray visualization of body cavities, of the formula:

摘要翻译： 用于体腔X射线可视化的碘多化合物，其配方如下：

公开(公告)号：US3676303A

公开(公告)日：1972-07-11

申请号：US3676303D

申请日：1969-01-14

申请人： PHARMACIA AB

发明人： INGELMAN BJORN G-A ,  CESKA MIROSLAV

IPC分类号： G01N23/00 ,  C08B31/00 ,  C12Q1/34 ,  G01N31/22 ,  G01N33/10 ,  G01N31/14

CPC分类号： C08B31/00 ,  C08B31/003 ,  C12Q1/34 ,  G01N2333/924

摘要： A METHOD FOR DETERMINING ENDOHYDROLASE WHICH BREAKS DOWN POLYSACHARIDE IN AN AQUIOUS SAMPLE WHICH COMPRISES CONTACTING THE SAMPLE WITH A REAGENT CONSISTING OF A WATER-INSOLUBLE BUT HYDROPHILIC, SWELLABLE, ENZYMATICALLY HYDROLYZABLE THREE-DIMENSIONAL NETWORK OF MOLECULES OF EITHER A POLSACCHARIDE OR AN ENZYMATICALLY HYDROLYZABLE DERIVATIVE OF A POLYSACCHARIDE. THE MOLECULES ARE CROSSLINKED WITH BONDS OF A COVALENT NATURE. ALSO THE THREE-DIMENSIONAL NETWORK PRESENTS INDICATABLE SUBSTITUENTS BOUND BY MEANS OF BONDS OF A COVALENT CHARACTER. THE CONTACTING CAUSES A REACTION TO TAKE PLACE BETWEEN THE ENZYME AND THE REAGENT WHEREBY WATER-SOLUBLE FRAGMENTS OF THE REAGENT CONTAINING INDICATABLE SUBSTITUENTS ARE RELEASED. THE UNDISSOLVED REAGENT IS SEPARATED FROM THE LIQUID WITH THE WATER-SOLUBLE FRAGMENTS OF THE REAGENT DISSOLVED THEREIN, AFTER THE ENZYME HAS ACTED UPON THE REAGENT FOR A DETERMINED PERIOD OF TIME. THE INDICATABLE SUBSTITUENTS ARE THEN DETERMINED IN AT LEAST ONE OF THE TWO PHASES CONSISTING OF THE LIQUID PHASE AND THE UNDISSOLVED REAGENT MATERIAL PHASE AS A MEASURE OF THE ENZYME ACTIVITY. ALSO, THE REAGENT FOR DETERMINING ENDOHYDROLASE IN PROVIDED.