公开(公告)号：US20150291956A1

公开(公告)日：2015-10-15

申请号：US14437923

申请日：2013-02-19

申请人： PHASERX, INC.

发明人： Markus Hossbach ,  Jochen Deckert

IPC分类号： C12N15/113

CPC分类号： C12N15/113 ,  C12N15/1135 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/343 ,  C12N2310/346 ,  C12N2310/3533 ,  C12N2310/3521

摘要： A double stranded RNA (dsRNA) molecule targeted to beta catenin includes a duplex region having a sense region and an antisense region at least substantially complementary to the sense region. The sense region and the antisense region each have between 18 and 30 nucleotides. The antisense region includes a nucleotide sequence that is fully complementary to at least 15 contiguous nucleotides of any one of SEQ ID NOs: 1-24.

摘要翻译： 靶向β-连环蛋白的双链RNA（dsRNA）分子包括具有至少基本上与感觉区域互补的有义区域和反义区域的双链体区域。 有义区域和反义区域各自具有18至30个核苷酸。 反义区域包括与SEQ ID NO：1-24中任一个的至少15个连续核苷酸完全互补的核苷酸序列。