公开(公告)号：US20210122757A1

公开(公告)日：2021-04-29

申请号：US17042646

申请日：2019-03-29

Applicant: PHENEX DISCOVERY VERWALTUNGS-GMBH

Inventor： Olaf KINZEL ,  Christoph STEENECK ,  Simon ANDERHUB ,  Martin HORNBERGER ,  Sheena PINTO ,  Barbara HERKERT ,  Thomas HOFFMANN

IPC: C07D491/048 ,  C07D307/94 ,  C07D209/96 ,  C07D405/06

Abstract: The present invention relates to novel spirocyclic compounds which act as modulators of indoleaine 2,3-dioxygenase (IDO1) and to the use of said compounds in the prophylaxis and/or treatment of diseases or conditions mediated by indoleamine 2,3-dioxygenase. The invention further relates to pharmaceutical compositions comprising the novel compounds.