公开(公告)号：US20220177546A1

公开(公告)日：2022-06-09

申请号：US17598029

申请日：2020-03-27

申请人： PHOENIX TISSUE REPAIR, INC.

发明人： Mark Desouza ,  Malini Viswanathan ,  Pierra-Alain Girod ,  Alexandre Regamey ,  Valerie Le Fourn ,  David Calabrese ,  John Gill ,  Megan Gottlieb ,  Amie Lundquist ,  Anna Tchoudakova ,  George Enriquez ,  Rahul Chelikani ,  Thomas Gagliardi ,  Tatiana Laivins ,  Hang Yuan

IPC分类号： C07K14/78 ,  C12N9/02

摘要： The present disclosure provides production systems and host cells to produce collagen 7 compositions comprising recombinant collagen 7 and/or functional variants thereof. The host cells are genetically engineered to stably express rCol7 and functional variants thereof. The collagen 7 composition can be used to restore collagen 7 levels in a subject in need, and for preventing, preventing the progression of, alleviating, and delaying the on-set of a skin condition, e.g., skin wound associated with dystrophic epidermolysis bullosa (DEB).