专利检索 ap:("PIERRE FABRE MEDICAMENT") AND inv:"Cyrille Dreyfus" 第 1 页

1.

发明授权
Sulfomaleimide-based linkers and corresponding conjugates 有权

公开(公告)号：US12011485B2

公开(公告)日：2024-06-18

申请号：US17280800

申请日：2019-09-27

申请人： PIERRE FABRE MEDICAMENT

发明人： Michel Perez , Frédéric Marion , Jean-François Haeuw , Cyrille Dreyfus

IPC分类号： A61K47/68 , A61K38/07 , A61K38/12 , A61K47/54 , A61P35/00

CPC分类号： A61K47/6849 , A61K38/07 , A61K38/12 , A61K47/545 , A61K47/6809 , A61K47/6811 , A61P35/00

摘要： The present invention relates to a linker of the following formula (I) or a salt thereof: (I). The present invention relates to a linker-drug conjugate of the following formula (II) or a salt thereof: (II). The present invention relates also to a binding unit-drug corrugate, such as an antibody-drug conjugate, of the following formula (III) or (IV) or a salt thereof: (III), (IV), as well as a pharmaceutical composition comprising such a binding unit-drug corrugate and its use in the treatment of cancer.