公开(公告)号：US20240301506A1

公开(公告)日：2024-09-12

申请号：US18636932

申请日：2024-04-16

Applicant: PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Inventor： Javier CERDA INFANTE ,  Viviana MONTECINOS ACUÑA

IPC: C12Q1/6886 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  G01N33/57434 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N2800/50

Abstract: Ex vivo method for the prognosis of metastasis in prostate cancer which comprises determining the level of expression of at least one of the following genes: NRP-1, MFAP4, NRIP3, THBS2, TNF, EDN1, EBF1 and GALNT16, in a biological sample that contains stromal cells of a prostate cancer primary tumor; and establish whether the expression of the genes NRP-1, MFAP4, NRIP3, THBS2, TNF, EDN1, EBF1 is increased or if the expression of the GALNT16 gene is diminished, which correlates with the prognosis of metastasis in prostate cancer. And a kit for predicting metastases in prostate cancer comprising means for quantifying the products of the genes NRP-1, MFAP4, NRIP3, THBS2, TNF, EDN1, EBF1 and GALNT16, in a sample comprising prostatic stromal cells.