公开(公告)号：US20230190848A1

公开(公告)日：2023-06-22

申请号：US18069902

申请日：2022-12-21

申请人： PONTIFICIA UNIVERSIDAD JAVERIANA ,  HOSPITAL UNIVERSITARIO SAN IGNACIO ,  DREEMBIO S.A.

发明人： Susana FIORENTINO GÓMEZ ,  Claudia Patricia URUEÑA PINZÓN ,  Alfonso BARRETO PRIETO ,  Karol PRIETO SARMIENTO ,  Alejandra GOMEZ CADENA ,  Ricardo BALLESTEROS-RAMIREZ ,  Angel Alberto GARCIA PENA ,  Pablo ASCHNER ,  Cindy Mayerly AREVALO OLAYA ,  Paola Veronica LASSO APRAEZ

IPC分类号： A61K36/48 ,  A61K31/192 ,  A61K31/216

CPC分类号： A61K36/48 ,  A61K31/192 ,  A61K31/216 ,  A61K2236/39 ,  A61K2236/31

摘要： The present invention provides compositions and methods for treating or prevent SARS-CoV-2 infections by delivering a therapeutically effective amount of a standardized P2Et extract enriched in polyphenol compounds from Caesalpinia spinosa that inhibits the production of coronavirus particles, reduces pulmonary fibrosis markers, down-regulates pro-inflammatory cytokines, and increases CD3+TL and CD3+CD4−CD8− T Lymphocytes subsets in COVID-19 patients. The disclosed compositions for treating or prevent SARS-CoV-2 infections comprising a standardized P2Et extract enriched in polyphenol compounds from Caesalpinia spinosa that may comprise one or more compounds selected from galloyl quinic acid and gallic acid derivatives and pharmaceutically acceptable excipients.