公开(公告)号：US20190307688A1

公开(公告)日：2019-10-10

申请号：US16330068

申请日：2017-09-01

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Hyung Joon CHA ,  Tae Yoon PARK ,  Hyo Jeong KIM ,  Bong Hyuk CHOI

IPC: A61K9/127 ,  A61K9/51 ,  A61K47/69 ,  C12N5/074

Abstract: The present disclosure relates to a novel stem cell carrier and a method for producing the same and provides a method for producing a stem cell carrier including a step of contacting stem cells with a coacervate formed by mixing an anionic polymer with a mussel adhesive protein or a mutant thereof. The present disclosure relates to a novel stem cell therapeutic agent platform of delivering cells in a encapsulated state by forming an adhesive cell carrier using crosslinked coacervate. The cell carrier of the present disclosure can maintain the ability to differentiate stem cells as well as biocompatibility and can survive without losing cell adhesion even under oxygen-deficient conditions. In addition, the cell carrier of the present disclosure has an excellent regenerative effect by applying such to biological tissues in which vascular regeneration is not easy, by inducing a metabolic reaction triggered by the hypoxic environment, in particular, neovascularization.