公开(公告)号：US11414667B2

公开(公告)日：2022-08-16

申请号：US16963315

申请日：2018-04-13

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Won Jong Kim ,  Ji Hyun Lee

IPC: C12N15/115 ,  A61K31/713 ,  C12Q1/6886

Abstract: The present invention relates to a highly efficient aptamer complex comprising a branched DNA and an aptamer, and a pharmaceutical use thereof. More specifically, the aptamer complex of the present invention relates to a highly efficient aptamer complex including a Y-shaped DNA as the branched DNA and using vascular endothelial growth factor (VEGF) as a target molecule. The aptamer complex of the present invention and a pharmaceutical composition comprising the same as an active ingredient are expected to be widely used in the medical field since the binding efficiency with the target molecule is more remarkable than that of the conventional aptamer.