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    ANALOGS OF PRIDOPIDINE, THEIR PREPARATION AND USE
    1.
    发明申请
    ANALOGS OF PRIDOPIDINE, THEIR PREPARATION AND USE 审中-公开

    公开(公告)号：US20200030308A1

    公开(公告)日：2020-01-30

    申请号：US16535107

    申请日：2019-08-08

    Applicant: PRILENIA NEUROTHERAPEUTICS LTD.

    Inventor： Malle SCHMIDT ,  Malle PARI ,  Marit LAOS ,  Ants MAASALU ,  Kalle KALJUSTE

    IPC: A61K31/451 ,  C07D211/52 ,  C07D211/24 ,  C07D211/42 ,  G01N30/88

    Abstract: This invention provides an isolated compound having the structure: or, or a salt thereof.The invention also provides for a process for preparing 4-(3-(methylsulfonyl)phenyl)-1-propylpiperidin-4-ol, 1-(3,3-bis(3-(methylsulfonyl)phenyl)propyl)-4-(3-(methylsulfonyl) phenyl)piperidone, 1,4-bis((3-(1-propylpiperidin-4-yl)phenyl)sulfonyl)butane, (3R,4S)-4-(3-(methylsulfonyl)phenyl)-1-propylpiperidin-3-ol, 4-(3-(methylsulfonyl)phenyl)-1-propylpiperidine 1-oxide, 1-(2-methylpentyl)-4-(3-(methylsulfonyl)phenyl)piperidine, 4-(3-(methylsulfinyl)phenyl)-1-propyl-1,2,3,6-tetrahydropyridine, and 4-(3-(methylsulfonyl)phenyl)-1-propyl-1,2,3,6-tetrahydropyridine.This invention also provides an impurity or a salt thereof for use, as a reference standard to detect trace amounts of the impurity in a pharmaceutical composition comprising pridopidine or a pharmaceutically acceptable salt thereof. This invention further provides a process for producing a pridopidine drug product comprising obtaining a pridopidine drug substance and mixing the pridopidine drug substance with suitable excipients so as to produce the pridopidine drug product. This invention also provides a process for producing a pridopidine drug product. This invention also provides a process of distributing a pridopidine drug product.

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