公开(公告)号：US20210106657A1

公开(公告)日：2021-04-15

申请号：US17130340

申请日：2020-12-22

申请人： PROMETIC BIOTHERAPEUTICS, INC.

发明人： DAVIDA BLACKMAN ,  STACY PLUM ,  WILLIAM GARZON-RODRIGUEZ ,  MARTIN ROBITAILLE ,  BETTY YU

IPC分类号： A61K38/48 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/26 ,  A61K9/19 ,  C12N9/68 ,  A61K9/00 ,  A61K9/08

摘要： Pharmaceutical compositions comprising plasminogen or a biologically active variant thereof are disclosed. In an embodiment, the composition comprises a tonicity modifier, a bulking agent, and a stabilising agent and has a pH of about 3.0 to about 10.0. In another embodiment, the composition contains an amount of particles in suspension equal to or greater than 10 μm which is lower than 6000 particles per 100 ml, and preferably lower than 2000 particles per 100 ml. Uses of these compositions as a medicament is contemplated. Various therapeutic uses of these pharmaceutical compositions is also contemplated.

公开(公告)号：US20200023043A1

公开(公告)日：2020-01-23

申请号：US16554011

申请日：2019-08-28

申请人： PROMETIC BIOTHERAPEUTICS, INC.

发明人： DAVIDA BLACKMAN ,  STACY PLUM ,  WILLIAM GARZON-RODRIGUEZ ,  MARTIN ROBITAILLE ,  BETTY YU

IPC分类号： A61K38/48 ,  A61K9/19 ,  A61K47/26 ,  A61K47/18 ,  A61K47/12 ,  A61K47/10 ,  A61K47/02 ,  A61K9/08 ,  A61K9/00 ,  C12N9/68

摘要： Pharmaceutical compositions comprising plasminogen or a biologically active variant thereof are disclosed. In an embodiment, the composition comprises a tonicity modifier, a bulking agent, and a stabilising agent and has a pH of about 3.0 to about 10.0. In another embodiment, the composition contains an amount of particles in suspension equal to or greater than 10 μm which is lower than 6000 particles per 100 ml, and preferably lower than 2000 particles per 100 ml. Uses of these compositions as a medicament is contemplated. Various therapeutic uses of these pharmaceutical compositions is also contemplated.

公开(公告)号：US20170360902A1

公开(公告)日：2017-12-21

申请号：US15536877

申请日：2015-12-18

申请人： PROMETIC BIOTHERAPEUTICS, INC.

发明人： DAVIDA BLACKMAN ,  STACY PLUM ,  WILLIAM GARZON-RODRIGUEZ ,  MARTIN ROBITAILLE ,  BETTY YU

IPC分类号： A61K38/48 ,  A61K47/18 ,  A61K47/12 ,  A61K47/10 ,  A61K47/02 ,  A61K47/26 ,  A61K9/19

CPC分类号： A61K38/484 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/19 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/183 ,  A61K47/26 ,  C12N9/6435 ,  C12Y304/21007

摘要： Pharmaceutical compositions comprising plasminogen or a biologically active variant thereof are disclosed. In an embodiment, the composition comprises a tonicity modifier, a bulking agent, and a stabilising agent and has a pH of about 3.0 to about 10.0. In another embodiment, the composition contains an amount of particles in suspension equal to or greater than 10 μm which is lower than 6000 particles per 100 ml, and preferably lower than 2000 particles per 100 ml. Uses of these compositions as a medicament is contemplated. Various therapeutic uses of these pharmaceutical compositions is also contemplated.