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公开(公告)号:US10995091B2
公开(公告)日:2021-05-04
申请号:US16167084
申请日:2018-10-22
申请人: Proximagen, LLC
发明人: Edward Daniel Savory , Alison Stewart , Allison Carley , Giles Brown , Iain Simpson , Kathryn Oliver , Lee Patient , Michael Higginbottom , Andrew Graham Cole
IPC分类号: A61K31/55 , A61K31/551 , A61K31/439 , A61K45/06 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/12 , C07D401/12 , C07B59/00 , C07D401/04 , C07D413/12 , C07D417/12
摘要: The compounds of formula (I) are antagonists of the CXCR4 receptor Wherein R1, X, Y and R2 are as defined in the claims.
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公开(公告)号:US10428066B2
公开(公告)日:2019-10-01
申请号:US15911935
申请日:2018-03-05
申请人: PROXIMAGEN, LLC
发明人: Max Espensen , Lee Patient , David Evans , Iain Simpson , Edward Savory
IPC分类号: A61K31/40 , C07D471/04 , C07C53/18
摘要: The compounds of formula (I) are inhibitors of SSAO activity wherein V, W, X, Y, Z, R1 and R2 are as defined in the claims.
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公开(公告)号:US10155761B2
公开(公告)日:2018-12-18
申请号:US15497324
申请日:2017-04-26
申请人: PROXIMAGEN, LLC
发明人: Edward Daniel Savory , Alison Stewart , Allison Carley , Giles Brown , Iain Simpson , Kathryn Oliver , Lee Patient , Michael Higginbottom , Andrew Graham Cole
IPC分类号: A61K31/55 , A61K31/551 , A61K31/439 , A61K45/06 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/12 , C07D401/12 , C07B59/00 , C07D401/04 , C07D413/12 , C07D417/12
摘要: The compounds of formula (I) are antagonists of the CXCR4 receptor Wherein R1, X, Y and R2 are as defined in the claims.
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公开(公告)号:US11530208B2
公开(公告)日:2022-12-20
申请号:US15506847
申请日:2015-09-17
申请人: PROXIMAGEN, LLC
发明人: Lee Patient , Iain Simpson , Edward Savory
IPC分类号: C07D471/04 , C07D403/04 , C07D403/14 , A61K31/436 , A61K31/437
摘要: A compound of formula (I) or a pharmaceutically acceptable salt, or N-oxide thereof and the use of the same in therapy: wherein Z, Y, R1, W, V, and R3 are as defined in claim 1.
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公开(公告)号:US10968223B2
公开(公告)日:2021-04-06
申请号:US16933417
申请日:2020-07-20
申请人: PROXIMAGEN, LLC
发明人: Max Espensen , Lee Patient , David Evans , Iain Simpson , Edward Savory
IPC分类号: C07D471/04 , A61K31/40 , A61K31/4745 , A61K31/495 , A61K31/501 , A61K31/506 , C07C53/18
摘要: A process for the preparation of a compound of formula (Ia) or a pharmaceutically acceptable salt, or N-oxide thereof that includes reacting a compound of formula (IIIa) or (Va) with a compound of formula (IX) to form the compound of formula (Ia)
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公开(公告)号:US10590125B2
公开(公告)日:2020-03-17
申请号:US15215026
申请日:2016-07-20
申请人: PROXIMAGEN, LLC
发明人: Max Espensen , Lee Patient , David Evans , Edward Savory , Iain Simpson
IPC分类号: C07D471/04 , A61K31/40 , C07C53/18
摘要: The present invention relates to compounds which are inhibitors of SSAO activity. The invention also relates to pharmaceutical compositions comprising these compounds and to the use of these compounds in the treatment or prevention of medical conditions wherein inhibition of SSAO activity is beneficial, such as inflammatory diseases, immune disorders and the inhibition of tumor growth.
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公开(公告)号:US20230110165A1
公开(公告)日:2023-04-13
申请号:US17962273
申请日:2022-10-07
申请人: Proximagen, LLC
发明人: Max Espensen , Lee Patient , David Evans , Edward Savory , Iain Simpson
IPC分类号: C07D471/04 , A61K31/40 , A61K31/4745 , A61K31/495 , A61K31/501 , A61K31/506 , C07C53/18
摘要: Compound of formula (I) or a pharmaceutically acceptable salt, or N-oxide thereof, that are inhibitors of SSAO activity: where V, W, X, Y, Z, R1, and R3 are as defined herein.
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公开(公告)号:US11512082B2
公开(公告)日:2022-11-29
申请号:US16784320
申请日:2020-02-07
申请人: PROXIMAGEN, LLC
发明人: Max Espensen , Lee Patient , David Evans , Edward Savory , Iain Simpson
IPC分类号: C07D471/04 , A61K31/40 , A61K31/4745 , A61K31/495 , A61K31/501 , A61K31/506 , C07C53/18
摘要: Compound of formula (I) or a pharmaceutically acceptable salt, or N-oxide thereof, that are inhibitors of SSAO activity: where V, W, X, Y, Z, R1, and R3 are as defined herein.
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公开(公告)号:US20220348577A1
公开(公告)日:2022-11-03
申请号:US17190266
申请日:2021-03-02
申请人: Proximagen, LLC
发明人: Giles Brown , Michael Higginbottom , Alison Stewart , Lee Patient , Allison Carley , Iain Simpson , Edward Daniel Savory , Kathryn Oliver , Andrew Graham Cole
IPC分类号: C07D471/08 , A61K45/06 , C07D405/14 , C07D413/14 , C07D417/14 , C07D401/14 , C07D401/12 , C07D471/04 , C07B59/00 , C07D401/04 , C07D413/12 , C07D417/12
摘要: The compounds of formula (I) are antagonists of the CXCR4 receptor Wherein R1, X, Y and R2 are as defined in the claims.
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公开(公告)号:US10766897B2
公开(公告)日:2020-09-08
申请号:US16542792
申请日:2019-08-16
申请人: PROXIMAGEN, LLC
发明人: Max Espensen , Lee Patient , David Evans , Iain Simpson , Edward Savory
IPC分类号: C07D471/04 , A61K31/40 , A61K31/4745 , A61K31/495 , A61K31/501 , A61K31/506 , C07C53/18
摘要: The compounds of formula (I) are inhibitors of SSAO activity wherein V, W, X, Y, Z, R1 and R2 are as defined in the claims.
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