公开(公告)号：US20240262806A1

公开(公告)日：2024-08-08

申请号：US18256099

申请日：2022-08-24

申请人： PTC THERAPEUTICS, INC.

发明人： XIAOYAN ZHANG ,  TIANYI ZHENG ,  SCOTT j BARRAZA ,  LAUREN BEJCEK ,  BRADLEY B GILBERT ,  HUA GONG ,  HANDOKO HANDOKO ,  SEYEDMORTEZA HOSSEYNI ,  EDUARDO HUARTE ,  WOOHYUNG JEON ,  JING LI ,  YAO LIU ,  KYLE NIEDERER ,  MEENU PILLAI ,  ERICA N PARKER ,  ETTORE RASTELLI ,  NADIYA SYDORENKO ,  ANTHONY TURPOFF ,  MATTHEW G WOLL ,  NANJING ZHANG ,  YAN ZHANG ,  RAUFUL ALAM

IPC分类号： C07D401/12 ,  A61K31/395 ,  A61K31/502 ,  A61K31/5025 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/55 ,  A61K31/551 ,  A61K31/553 ,  C07D237/34 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D498/04 ,  C07D519/00

CPC分类号： C07D401/12 ,  A61K31/502 ,  A61K31/5025 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/55 ,  A61K31/551 ,  A61K31/553 ,  A61K31/5545 ,  C07D237/34 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D498/04 ,  C07D519/00

摘要： The present invention relates to novel compounds of Formulae I-XI: wherein each A, A′, Q, Q′, W, Rw, Y, and Z, and -- are as defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in the treatment of diseases and disorders mediated by NLRP3.