公开(公告)号：US20250025523A1

公开(公告)日：2025-01-23

申请号：US18713025

申请日：2022-11-23

Applicant: PUKYONG NATIONAL UNIVERSITY INDUSTRY- UNIVERSITY COOPERATION FOUNDATION

Inventor： Bonggi LEE ,  Hyeung-Rak KIM ,  Min-Kyeong LEE ,  Myeong-Jin KIM ,  Jiwon BAEK ,  Heeyeon RYU

IPC: A61K36/03 ,  A61P21/00

Abstract: The present invention relates to a composition for the prevention or treatment of muscle diseases comprising a Sargassum serratifolium extract. The Sargassum serratifolium extract of the present invention has been found to protect muscle cells from dexamethasone-induced atrophy and muscle loss caused by the side effects of atorvastatin, inhibit the reduction in myotube diameter, suppress muscle atrophy, induce muscle hypertrophy, and inhibit muscle protein degradation. Additionally, in an animal model with dexamethasone-induced muscle atrophy, it was confirmed to increase muscle strength, improve muscle function, and increase muscle mass, making it useful for the prevention or treatment of muscle diseases.