专利检索 ap:("Pandurang Balwant Deshpande" OR "Anand Kumar Randey" OR "Dharmesh Ramniklal Dhameliya" OR "Bhimsing Rathod Dayawant" OR "Parven Kumar Luthra") AND inv:"Dharmesh Ramniklal Dhameliya" 第 1 页

1.

发明申请
PROCESS FOR THE PREPARATION OF ENTACAPONE 审中-公开
标题翻译：制备ENTACAPONE的方法

公开(公告)号：US20100234632A1

公开(公告)日：2010-09-16

申请号：US12377643

申请日：2007-08-13

申请人： Pandurang Balwant Deshpande , Anand Kumar Randey , Dharmesh Ramniklal Dhameliya , Bhimsing Rathod Dayawant , Parven Kumar Luthra

发明人： Pandurang Balwant Deshpande , Anand Kumar Randey , Dharmesh Ramniklal Dhameliya , Bhimsing Rathod Dayawant , Parven Kumar Luthra

IPC分类号： C07C253/30

CPC分类号： C07C253/30 , C07C255/41

摘要： The present invention relates to an improved process for the preparation of Entacapone of formula (I) comprising a step of, condensation of 3,4-dihydroxy-5-nitrobenzaldehyde of formula (II) with N,N-diethylcyanoacetamide of formula (III) in the presence of two component solvent system, a catalyst and optionally a phase transfer catalyst to give Entacapone of formula (I).

摘要翻译： 本发明涉及制备式（I）的恩他卡宾的改进方法，其包括将式（II）的3,4-二羟基-5-硝基苯甲醛与式（III）的N，N-二乙基氰基乙酰胺缩合的步骤，在双组分溶剂体系的存在下，催化剂和任选的相转移催化剂，得到式（I）的恩他卡朋。