专利检索 ap:("Pascal Chaux" OR "Rosalie Luiten" OR "Nathalie Demotte" OR "Marie-Therese Duffour" OR "Christophe Lurquin" OR "Catia Traversari" OR "Vincent Stroobant" OR "Guy Cornelis" OR "Thiery Boon-Falleur" OR "Pierre van der Bruggen") AND inv:"Guy Cornelis" 第 1 页

1.

发明授权
Tumor antigens and CTL clones isolated by a novel procedure 有权

公开(公告)号：US06531451B1

公开(公告)日：2003-03-11

申请号：US09289350

申请日：1999-04-09

申请人： Pascal Chaux , Rosalie Luiten , Nathalie Demotte , Marie-Therese Duffour , Christophe Lurquin , Catia Traversari , Vincent Stroobant , Guy Cornelis , Thiery Boon-Falleur , Pierre van der Bruggen

发明人： Pascal Chaux , Rosalie Luiten , Nathalie Demotte , Marie-Therese Duffour , Christophe Lurquin , Catia Traversari , Vincent Stroobant , Guy Cornelis , Thiery Boon-Falleur , Pierre van der Bruggen

IPC分类号： A61K3800

CPC分类号： C07K14/4748

摘要： The present invention relates to isolation of cytotoxic T lymphocyte (CTL) clones. In particular, the present invention relates to isolated CTL clones that are specific for MAGE-1 and MAGE-4, respectively. The CTL clones of the present invention have been isolated by successive steps of stimulation and testing of lymphocytes with antigen presenting cells which present antigens derived from different expression systems, e.g., from recombinant Yersinia, recombinant Salmonella, or recombinant viruses. The present invention further relates to the MAGE-1 and MAGE-4 antigenic peptides as well as the peptide/HLA complexes which are recognized by the isolated CTL clones.