-
公开(公告)号:US06291430B1
公开(公告)日:2001-09-18
申请号:US09166448
申请日:1998-10-05
申请人: Pascal Chaux , Vincent Stroobant , Thierry Boon-Falleur , Pierre van der Bruggen , Kris Thielemans , Jurgen Kurthals
发明人: Pascal Chaux , Vincent Stroobant , Thierry Boon-Falleur , Pierre van der Bruggen , Kris Thielemans , Jurgen Kurthals
IPC分类号: A61K3804
CPC分类号: C07K14/4748 , A61K39/00 , C07K2319/00
摘要: The invention describes HLA class II binding peptides encoded by the MAGE-3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the MAGE-3 gene.
摘要翻译: 本发明描述了由MAGE-3肿瘤相关基因编码的HLA II类结合肽,以及编码这样的肽和与之有关的抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以MAGE-3基因表达为特征的病症的方法和产品。
-
公开(公告)号:US07252825B2
公开(公告)日:2007-08-07
申请号:US10170832
申请日:2002-06-12
申请人: Pascal Chaux , Vincent Stroobant , Thierry Boon-Falleur , Pierre van der Bruggen , Kris Thielemans , Jurgen Kurthals
发明人: Pascal Chaux , Vincent Stroobant , Thierry Boon-Falleur , Pierre van der Bruggen , Kris Thielemans , Jurgen Kurthals
IPC分类号: A61K39/00
CPC分类号: C07K14/4748 , A61K39/00 , C07K2319/00
摘要: The invention describes HLA class II binding peptides encoded by the MAGE-3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the MAGE-3 gene.
摘要翻译: 本发明描述了由MAGE-3肿瘤相关基因编码的HLA II类结合肽,以及编码这样的肽和与之有关的抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以MAGE-3基因表达为特征的病症的方法和产品。
-
公开(公告)号:US06426217B1
公开(公告)日:2002-07-30
申请号:US09697884
申请日:2000-10-27
申请人: Pascal Chaux , Vincent Stroobant , Thierry Boon-Falleur , Pierre van der Bruggen , Kris Thielemans , Jurgen Kurthals
发明人: Pascal Chaux , Vincent Stroobant , Thierry Boon-Falleur , Pierre van der Bruggen , Kris Thielemans , Jurgen Kurthals
IPC分类号: C12N100
CPC分类号: C07K14/4748 , A61K39/00 , C07K2319/00
摘要: The invention describes HLA class II binding peptides encoded by the MAGE-3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the MAGE-3 gene.
摘要翻译: 本发明描述了由MAGE-3肿瘤相关基因编码的HLA II类结合肽,以及编码这样的肽和与之有关的抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以MAGE-3基因表达为特征的病症的方法和产品。
-
-