公开(公告)号：US11638809B2

公开(公告)日：2023-05-02

申请号：US16911181

申请日：2020-06-24

申请人： PASSPORT TECHNOLOGIES, INC.

发明人： Hirotoshi Adachi ,  Shohei Horie ,  Akinori Hanatani ,  Masato Nishimura ,  Yuki Yamada ,  Joe Hua

IPC分类号： A61M37/00 ,  A61K9/70 ,  A61K31/4196 ,  A61K31/4045 ,  A61K47/40 ,  A61K47/26 ,  A61K47/12 ,  A61K31/422 ,  A61N1/32

摘要： A transdermal delivery system for delivery of a triptan into a tissue membrane of a subject. The system includes a transdermal microporation apparatus for heating a skin surface and a triptan drug delivery patch. The drug delivery patch comprises a top layer comprising an adhesive, a middle layer comprising the triptan, and a bottom layer. A method for treating a subject comprises identifying a subject having a migraine, using the transdermal microporation apparatus to open a plurality of micropores in the skin of the subject, and applying the triptan drug delivery patch to the subject's skin over the micropores for a period of time effective to deliver the triptan through the micropores in an amount effective to treat the subject's migraine.

公开(公告)号：US20230264004A1

公开(公告)日：2023-08-24

申请号：US18310041

申请日：2023-05-01

申请人： PassPort Technologies, Inc.

发明人： Hirotoshi Adachi ,  Shohei Horie ,  Akinori Hanatani ,  Masato Nishimura ,  Yuki Yamada ,  Joe Hua

IPC分类号： A61M37/00 ,  A61K9/70 ,  A61K31/4196 ,  A61K31/4045 ,  A61K47/40 ,  A61K47/26 ,  A61K47/12 ,  A61K31/422

CPC分类号： A61M37/00 ,  A61K9/7084 ,  A61K31/4196 ,  A61K31/4045 ,  A61K47/40 ,  A61K47/26 ,  A61K47/12 ,  A61K31/422 ,  A61N1/327

摘要： A transdermal delivery system for delivery of a triptan into a tissue membrane of a subject. The system includes a transdermal microporation apparatus for heating a skin surface and a triptan drug delivery patch. The drug delivery patch comprises a top layer comprising an adhesive, a middle layer comprising the triptan, and a bottom layer. A method for treating a subject comprises identifying a subject having a migraine, using the transdermal microporation apparatus to open a plurality of micropores in the skin of the subject, and applying the triptan drug delivery patch to the subject's skin over the micropores for a period of time effective to deliver the triptan through the micropores in an amount effective to treat the subject's migraine.