公开(公告)号：US06673352B1

公开(公告)日：2004-01-06

申请号：US09662341

申请日：2000-09-14

申请人： Patricia K. Donahoe ,  Jose Teixeira ,  Eric Fynn-Thompson

发明人： Patricia K. Donahoe ,  Jose Teixeira ,  Eric Fynn-Thompson

IPC分类号： A61K3900

CPC分类号： A61K38/22 ,  A61K48/00

摘要： The present invention provides a method of treating a condition or disease characterized by an excess of one or more androgens, the method comprising administering an effective amount of MIS protein or nucleic acid encoding MIS to a patient. The present invention also provides a method of decreasing the level of one or more androgens to a level below the normal level, the method comprising administering an effective amount of MIS protein or nucleic acid encoding MIS to a patient. The methods of the present invention are particularly well-suited for the treatment of prostatic cancer, polycystic ovarian disease, benign prostatic hypertrophy, and precocious puberty.

摘要翻译： 本发明提供一种治疗特征在于过量一种或多种雄激素的病症或疾病的方法，所述方法包括向患者施用有效量的MIS蛋白或编码MIS的核酸。 本发明还提供了将一种或多种雄激素的水平降低到低于正常水平的水平的方法，所述方法包括向患者施用有效量的MIS蛋白或编码MIS的核酸。 本发明的方法特别适用于治疗前列腺癌，多囊卵巢疾病，良性前列腺肥大和早熟性青春期。