专利检索 ap:("Patricia S. Campbell" OR "David J. Enscore" OR "Robert M. Gale" OR "Arnold Kaufman") AND inv:"Arnold Kaufman" 第 1 页

1.

发明授权
Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix 失效
标题翻译：用于防止在单水基质中的液体分散体中形成结晶水合物的方法

公开(公告)号：US4832953A

公开(公告)日：1989-05-23

申请号：US85052

申请日：1987-08-13

申请人： Patricia S. Campbell , David J. Enscore , Robert M. Gale , Arnold Kaufman

发明人： Patricia S. Campbell , David J. Enscore , Robert M. Gale , Arnold Kaufman

IPC分类号： A61K9/70

CPC分类号： A61K9/7053 , A61K9/7084

摘要： A method for preventing the formation of crystalline hydrates in a dispersion of a hydratable liquid in a nonaqueous matrix is disclosed. The method is particularly useful in the manufacture of laminated items formed from such dispersions and comprises forming individual subunits from such dispersions, heating the subunits, preferably after they have been packed in sealed containers, to a temperature high enough to melt the crystalline hydrate, maintaining said subunits at such temperature for a time sufficient to melt all the crystalline hydrate present and to prevent the occurrence of crystals for an extended period of time after cooling and cooling subunits to ambient conditions. The use of the method in the manufacture of transdermal delivery devices for the delivery of scopolamine base is described.