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公开(公告)号：US5198229A
公开(公告)日：1993-03-30
申请号：US710607
申请日：1991-06-05
IPC分类号： A61K9/00
CPC分类号： A61K9/0065 , A61K9/0004
摘要： The present invention is directed to a fluid-imbibing drug delivery device having a first, low density such that it floats in the stomach contents for a predetermined prolonged period of time, during which prolonged period of time it dispenses a drug or other active agent to the stomach, and having a second, higher density such that the device exits the stomach at the end of the predetermined prolonged period of time.
摘要翻译： 本发明涉及一种流体吸收药物递送装置，其具有第一低密度，使得其在胃内容物中漂浮预定的较长时间段，在此期间，其将药物或其它活性剂分配到 胃，并且具有第二较高密度，使得装置在预定的较长时间段结束时离开胃。
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公开(公告)号：US5443459A
公开(公告)日：1995-08-22
申请号：US109120
申请日：1993-08-19
CPC分类号： A61K9/0004 , A61K9/4808
摘要： The present invention is directed to a fluid-imbibing dispensing device for the initially delayed delivery of an active agent to a fluid environment of use and to a method of using the dispensing device. The dispenser comprises a housing having a first wall section and a second wall section in reversibly sliding telescopic arrangement with each other, which housing maintains its integrity in the environment of use; an internal compartment surrounded and defined by the housing; at least one active agent formulation in the compartment; and expansion means and a push plate in the compartment for separating apart the first and second wall sections of the housing after exposure to the environment of use to expose the active agent formulation to the environment of use.
摘要翻译： 本发明涉及用于将活性剂最初延迟递送到使用的流体环境的流体吸入分配装置以及使用分配装置的方法。 所述分配器包括壳体，所述壳体具有彼此可逆地滑动伸缩布置的第一壁部分和第二壁部分，所述壳体在使用环境中保持其完整性; 由壳体包围和限定的内部隔室; 隔室中的至少一种活性剂制剂; 以及膨胀装置和隔室中的推板，用于在暴露于使用环境之后将壳体的第一和第二壁部分分开以将活性剂制剂暴露于使用环境。
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公开(公告)号：US5340590A
公开(公告)日：1994-08-23
申请号：US88931
申请日：1993-07-08
CPC分类号： A61K9/0004 , A61K9/4808 , A61M31/002
摘要： A dispenser for use in a fluid environment which is capable of delivery of a plurality of discrete drug-containing units in any desired delivery pattern or profile.
摘要翻译： 用于流体环境中的分配器，其能够以任何期望的递送模式或轮廓递送多个离散的含药单元。
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公开(公告)号：US5236689A
公开(公告)日：1993-08-17
申请号：US873901
申请日：1992-04-24
CPC分类号： A61M31/002 , A61K9/0004 , A61K9/4808
摘要： A dispenser for use in a fluid environment which is capable of delivery of a plurality of discrete drug-containing units in any desired delivery pattern or profile.
摘要翻译： 用于流体环境中的分配器，其能够以任何期望的递送模式或轮廓递送多个离散的含药单元。
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公开(公告)号：US5417682A
公开(公告)日：1995-05-23
申请号：US186046
申请日：1994-01-21
CPC分类号： A61K9/0004 , A61K9/4808
摘要： The present invention is directed to a fluid-imbibing dispensing device for the immediate or almost immediate and extended delivery of an active agent over a prolonged period of time together with the initially delayed pulse delivery of an active agent to a fluid environment of use. The dispenser comprises a housing having a first wall section and a second wall section in slidably telescoping arrangement with each other, which housing maintains its integrity in the environment of use; an internal compartment surrounded and defined by the housing; a first active agent delivery chamber within a portion of the compartment defined by the first wall section, the first delivery chamber including at least one active agent formulation, an exit means for providing communication between the active agent formulation and the environment, and a first expansion means for dispensing the first active agent formulation through the exit means to the environment immediately and over a prolonged period of time; a second active agent delivery chamber within a portion of the compartment defined by the first wall section and adjacent the open end of the first wall section, the second delivery chamber including at least one active agent formulation; and an expansion chamber within a portion of the compartment defined by the second wall section, for separating apart the first and second wall sections of the housing after exposure to the environment of use for dispensing the second active agent formulation to the environment in a pulse after an initially delayed period of time, the expansion chamber including a second expansion means and a partition layer or push plate.
摘要翻译： 本发明涉及一种流体吸入分配装置，用于在延长的时间段内立即或几乎立即和延长地递送活性剂，同时将活性剂的初始延迟脉冲输送到使用的流体环境。 分配器包括具有彼此可滑动地伸缩布置的第一壁部分和第二壁部分的壳体，该壳体在使用环境中保持其完整性; 由壳体包围和限定的内部隔室; 第一活性剂递送室，位于由第一壁部限定的隔室的一部分内，第一递送室包括至少一种活性剂制剂，用于提供活性剂配方与环境之间的连通的出口装置，以及第一膨胀 用于通过出口装置将第一活性剂制剂直接和长时间地分配到环境的装置; 第二活性剂递送室，其在由第一壁部分限定并且邻近第一壁部分的开口端限定的隔室的一部分内，第二递送室包括至少一种活性剂制剂; 以及在由所述第二壁部限定的所述隔室的一部分内的膨胀室，用于在暴露于使用环境之后分离所述壳体的所述第一和第二壁部分，以在所述第二活性剂配方的环境中以脉冲分配所述环境 最初延迟的时间段，膨胀室包括第二膨胀装置和分隔层或推板。
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公开(公告)号：US5391381A
公开(公告)日：1995-02-21
申请号：US60372
申请日：1993-05-11
CPC分类号： A61K9/0004 , A61K9/4808 , A61M31/002
摘要： A dispenser for use in a fluid environment which is capable of delivery of a plurality of discrete drug-containing units in any desired delivery pattern or profile.
摘要翻译： 用于流体环境中的分配器，其能够以任何期望的递送模式或轮廓递送多个离散的含药单元。
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公开(公告)号：US5110597A
公开(公告)日：1992-05-05
申请号：US701927
申请日：1991-05-17
CPC分类号： A61K9/0004 , A61K9/4808 , A61M31/002
摘要： A dispenser for use in a fluid environment which is capable of delivery of a plurality of discrete drug-containing units in any desired delivery pattern or profile.
摘要翻译： 用于流体环境中的分配器，其能够以任何期望的递送模式或轮廓递送多个离散的含药单元。
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公开(公告)号：US5023088A
公开(公告)日：1991-06-11
申请号：US495825
申请日：1990-03-19
CPC分类号： A61M31/002 , A61K9/0004 , A61K9/4808
摘要： A dispenser for use in a fluid environment which is capable of delivery of a plurality of discrete drug-containing units in any desired delivery pattern or profile.
摘要翻译： 用于流体环境中的分配器，其能够以任何期望的递送模式或轮廓递送多个离散的含药单元。
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公开(公告)号：US4986987A
公开(公告)日：1991-01-22
申请号：US312845
申请日：1989-02-21
申请人： Atul D. Ayer , Felix Theeuwes , Patrick S. L. Wong
发明人： Atul D. Ayer , Felix Theeuwes , Patrick S. L. Wong
IPC分类号： A61K9/00
CPC分类号： A61K9/0004
摘要： A dosage form comprising (1) an immediately available dose of a beneficial drug followed by a timed delayed dose of drug, or (2) a timed delayed dose of drug.
摘要翻译： 一种剂型，其包含（1）立即可用的有效药物剂量，然后是药物的定时延迟剂量，或（2）定时延迟剂量的药物。
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公开(公告)号：US4957494A
公开(公告)日：1990-09-18
申请号：US283631
申请日：1988-12-13
CPC分类号： A61M31/002 , A61K9/0004
摘要： A dispenser for use in a fluid environment which is capable of delivery of plurality of discrete drug containing layers in any desired delivery pattern or profile. The dispenser comprises a rigid housing containing a plurality of drug layers which may be separated by drug-free layers. An outlet is provided at one end of the housing and a fluid actuated driving means is provided between the other end of the housing and the drug layers. The portion of the housing in proximity to the driving means has a controlled permeability to water whereby, upon immersion in a fluid environment the drug layers are driven towards the outlet. Various delivery patterns are possible by appropriate selection of the comparison and dimensions of the drug and drug-free layers.
摘要翻译： 一种在流体环境中使用的分配器，其能够以任何期望的输送模式或轮廓递送多个离散的含药层。 分配器包括容纳多个药物层的刚性壳体，其可由无药物层分离。 出口设在壳体的一端，并且流体驱动的驱动装置设置在壳体的另一端和药物层之间。 壳体靠近驱动装置的部分对水具有受控的渗透性，因此当浸入流体环境中时，药物层朝着出口被驱动。 可以通过适当选择药物和无药物层的比较和尺寸来实现各种递送模式。
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