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公开(公告)号：US4915949A
公开(公告)日：1990-04-10
申请号：US312270
申请日：1989-02-21
CPC分类号： A61K9/0068 , A61K9/0004
摘要： A dispenser is disclosed for delivering tiny pills to an environment of use. The dispenser comprising a wall that surrounds an internal space comprising a first mean in the dispenser for changing from a dispenser state to an environment of use state on leaving the dispenser, tiny pills in the first means, and a second means in the dispenser for aiding in displacing the first means for the dispenser.
摘要翻译： 公开了用于将微小丸剂递送到使用环境的分配器。 所述分配器包括围绕内部空间的壁，所述壁包括所述分配器中的第一平均值，用于在离开所述分配器时从分配器状态改变为使用状态，所述第一装置中的小丸和用于辅助的所述分配器中的第二装置 在移动分配器的第一装置时。
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公开(公告)号：US4940465A
公开(公告)日：1990-07-10
申请号：US268401
申请日：1988-11-07
CPC分类号： A61M31/002 , A61K9/0004
摘要： A dispenser is enclosed for delivering a beneficial agent to an environment of use. The dispenser comprising a wall that surrounds an internal space comprising a first means in the dispenser for changing from a dispenser state to an environment of use state on leaving the dispenser, a beneficial agent in the first means, and a second means in the dispenser for aiding in displacing the first means from the dispenser.
摘要翻译： 封闭的分配器用于将有益剂递送到使用环境中。 分配器包括围绕内部空间的壁，包括分配器中的第一装置，用于在离开分配器时从分配器状态改变为使用状态，第一装置中的有益剂，以及分配器中的第二装置， 有助于从分配器移位第一装置。
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公开(公告)号：US4892778A
公开(公告)日：1990-01-09
申请号：US054714
申请日：1987-05-27
CPC分类号： A61M31/002 , A61K9/0004 , Y10S428/913 , Y10T428/24992 , Y10T428/31504 , Y10T428/31511 , Y10T428/31909 , Y10T428/31978
摘要： A dispenser is enclosed for delivering a beneficial agent to an enviroment of use. The dispenser comprising a wall that surrounds an internal space comprising a first mean in the dispenser for changing from a dispenser state to an environment of use state on leaving the dispenser, a beneficial agent in the first means, and a second means in the dispenser for aiding in displacing the first means from the dispenser.
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公开(公告)号：US4824675A
公开(公告)日：1989-04-25
申请号：US72506
申请日：1987-07-13
CPC分类号： A61K9/0068 , A61K9/0004
摘要： A dispenser is disclosed for delivering tiny pills to an environment of use. The dispenser comprising a wall that surrounds an internal space comprising a first mean in the dispenser for changing from a dispenser state to an environment of use state on leaving the dispenser, tiny pills in the first means, and a second means in the dispenser for aiding in displacing the first means for the dispenser.
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公开(公告)号：US4957494A
公开(公告)日：1990-09-18
申请号：US283631
申请日：1988-12-13
CPC分类号： A61M31/002 , A61K9/0004
摘要： A dispenser for use in a fluid environment which is capable of delivery of plurality of discrete drug containing layers in any desired delivery pattern or profile. The dispenser comprises a rigid housing containing a plurality of drug layers which may be separated by drug-free layers. An outlet is provided at one end of the housing and a fluid actuated driving means is provided between the other end of the housing and the drug layers. The portion of the housing in proximity to the driving means has a controlled permeability to water whereby, upon immersion in a fluid environment the drug layers are driven towards the outlet. Various delivery patterns are possible by appropriate selection of the comparison and dimensions of the drug and drug-free layers.
摘要翻译： 一种在流体环境中使用的分配器，其能够以任何期望的输送模式或轮廓递送多个离散的含药层。 分配器包括容纳多个药物层的刚性壳体，其可由无药物层分离。 出口设在壳体的一端，并且流体驱动的驱动装置设置在壳体的另一端和药物层之间。 壳体靠近驱动装置的部分对水具有受控的渗透性，因此当浸入流体环境中时，药物层朝着出口被驱动。 可以通过适当选择药物和无药物层的比较和尺寸来实现各种递送模式。
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公开(公告)号：US5391381A
公开(公告)日：1995-02-21
申请号：US60372
申请日：1993-05-11
CPC分类号： A61K9/0004 , A61K9/4808 , A61M31/002
摘要： A dispenser for use in a fluid environment which is capable of delivery of a plurality of discrete drug-containing units in any desired delivery pattern or profile.
摘要翻译： 用于流体环境中的分配器，其能够以任何期望的递送模式或轮廓递送多个离散的含药单元。
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公开(公告)号：US5110597A
公开(公告)日：1992-05-05
申请号：US701927
申请日：1991-05-17
CPC分类号： A61K9/0004 , A61K9/4808 , A61M31/002
摘要： A dispenser for use in a fluid environment which is capable of delivery of a plurality of discrete drug-containing units in any desired delivery pattern or profile.
摘要翻译： 用于流体环境中的分配器，其能够以任何期望的递送模式或轮廓递送多个离散的含药单元。
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公开(公告)号：US5023088A
公开(公告)日：1991-06-11
申请号：US495825
申请日：1990-03-19
CPC分类号： A61M31/002 , A61K9/0004 , A61K9/4808
摘要： A dispenser for use in a fluid environment which is capable of delivery of a plurality of discrete drug-containing units in any desired delivery pattern or profile.
摘要翻译： 用于流体环境中的分配器，其能够以任何期望的递送模式或轮廓递送多个离散的含药单元。
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公开(公告)号：US5938654A
公开(公告)日：1999-08-17
申请号：US382947
申请日：1995-02-01
CPC分类号： A61K9/0004 , A61K9/4808
摘要： A dispenser for use in a fluid environment of use which is capable of the delivery of one or a plurality of discrete active agent-containing units in any desired delivery pattern or profile. It also can provide for the initially delayed delivery of an active agent to the environment of use and for high accuracy in the timing of delivery of the active agent.
摘要翻译： 一种在流体使用环境中使用的分配器，其能够以任何期望的递送模式或轮廓递送一个或多个离散的含活性剂的单元。 它还可以提供活性剂在使用环境中的最初延迟递送以及在活性剂递送时间上的高精度。
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公开(公告)号：US4874388A
公开(公告)日：1989-10-17
申请号：US66906
申请日：1987-06-25
CPC分类号： A61M31/002 , A61K9/0004
摘要： A dispenser for use in a fluid environment having a rigid housing containing a fluid activated driving member, a plurality of drug containing layers and an outlet means by which drug is dispensed to the environment. The housing adjacent to the layers is fluid impermeable and the housing adjacent to the driving member is fluid permeable or has an open area by which fluid can contact the driving member. O048743884
摘要翻译： 一种在流体环境中使用的分配器，其具有容纳流体激活的驱动构件，多个药物容纳层的刚性壳体和药物分配到环境中的出口装置。 与层相邻的壳体是流体不可渗透的，并且与驱动构件相邻的壳体是流体可渗透的或具有开口区域，流体可以通过该开口区域接触驱动构件。 O048743884
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