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公开(公告)号：US20120190031A1
公开(公告)日：2012-07-26
申请号：US13203531
申请日：2010-03-25
IPC分类号： C12Q1/68
CPC分类号： G01N33/6869 , G01N33/6896 , G01N2333/545 , G01N2800/285
摘要： The invention provides an improved method for monitoring the course of the MS disease and to predict, diagnose or prognosticate whether a subject is in an active or non-active period of MS. The method is based on determining the ratio of the expression levels of two cytokines, measured before and after stimulation of the subject by an immunomodulator.
摘要翻译： 本发明提供了一种用于监测MS疾病进程并预测，诊断或预测受试者是否处于MS的活动期或非活动期的改进方法。 该方法基于通过免疫调节剂测定受试者刺激之前和之后测量的两种细胞因子的表达水平的比例。
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2.发明申请METHOD FOR EVALUATING THE RESPONSE OF AN INDIVIDUAL TO A TREATMENT WITH A TYPE I INTERFERON (IFN) 失效用于评估个体对I型干扰素（IFN）的治疗反应的方法公开(公告)号：US20100129788A1
公开(公告)日：2010-05-27
申请号：US12522623
申请日：2008-01-24
IPC分类号： C12Q1/70
CPC分类号： C12Q1/707 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158
摘要： A method for evaluating the in vivo presence of a factor that prevents the biological effect of a type I (IFN) in an individual that is under treatment with type I interferon is described. The in vivo presence of antibodies directed against a type I interferon (IFN) is evaluated in an individual that is under treatment with type I interferon. The method includes incubating a blood sample of the individual in vitro with a suitable amount of the type I interferon for a suitable period of time, and determining mRNA levels of a biological marker of IFN activity, preferably M×A, in the blood sample. The treatment may involve a treatment of multiple sclerosis, HCV or HBV using a type I interferon.
摘要翻译： 描述了用于评估在I型干扰素治疗的个体中预防I型（IFN）的生物学作用的因子的体内存在的方法。 在用I型干扰素治疗的个体中评估针对I型干扰素（IFN）的抗体的体内存在。 该方法包括将体外血液样品与适量的I型干扰素孵育合适的时间，并测定血液样品中IFN活性，优选M×A的生物学标志物的mRNA水平。 该治疗可涉及使用I型干扰素治疗多发性硬化症，HCV或HBV。
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3.发明授权Method for evaluating the response of an individual to a treatment with a type I interferon (IFN) 失效评价个体对I型干扰素（IFN）治疗反应的方法公开(公告)号：US08426170B2
公开(公告)日：2013-04-23
申请号：US12522623
申请日：2008-01-24
IPC分类号： C12P19/34
CPC分类号： C12Q1/707 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158
摘要： A method for evaluating the in vivo presence of a factor that prevents the biological effect of a type I (IFN) in an individual that is under treatment with type I interferon is described. The in vivo presence of antibodies directed against a type I interferon (IFN) is evaluated in an individual that is under treatment with type I interferon. The method includes incubating a blood sample of the individual in vitro with a suitable amount of the type I interferon for a suitable period of time, and determining mRNA levels of a biological marker of IFN activity, preferably MxA, in the blood sample. The treatment may involve a treatment of multiple sclerosis, HCV or HBV using a type I interferon.
摘要翻译： 描述了用于评估在I型干扰素治疗的个体中预防I型（IFN）的生物学作用的因子的体内存在的方法。 在用I型干扰素治疗的个体中评估针对I型干扰素（IFN）的抗体的体内存在。 该方法包括将体外血液样品与合适量的I型干扰素孵育合适的时间，并测定血液样品中IFN活性生物学标志物，优选MxA的mRNA水平。 该治疗可涉及使用I型干扰素治疗多发性硬化症，HCV或HBV。
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公开(公告)号：US20080038760A1
公开(公告)日：2008-02-14
申请号：US11629030
申请日：2005-06-06
申请人： Francoise Mascart , Annick Ocmant
发明人： Francoise Mascart , Annick Ocmant
IPC分类号： G01N33/00
CPC分类号： G01N33/564 , G01N2333/9108
摘要： Methods for detecting anti-transglutaminase antibodies in a saliva sample containing the antibodies are disclosed. Saliva samples are pre-treated. The antibodies are subsequently detected in the pre-treated saliva by an immune reaction with a transglutaminase under conditions suitable for forming immuno-complexes with the antibodies. The method is useful for diagnosing and/or therapeutically controlling celiac disease.
摘要翻译： 公开了在含有抗体的唾液样品中检测抗转谷氨酰胺酶抗体的方法。 唾液样品经过预处理。 随后在适合与抗体形成免疫复合物的条件下，通过与转谷氨酰胺酶的免疫反应在预处理的唾液中检测抗体。 该方法可用于诊断和/或治疗性控制乳糜泻。
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