专利检索 ap:("Paul B. Savage" OR "Saurabh Shashikant Chitre" OR "Kunal Arvind Varia" OR "Hayley Ann Reece" OR "Thomas E. Jacks" OR "Ross A. Miller" OR "Jared Lynn Randall") AND inv:"Saurabh Shashikant Chitre" 第 1 页

1.

发明申请
CATIONIC STEROIDAL ANTIMICROBIAL SALTS 审中-公开

公开(公告)号：US20170174720A9

公开(公告)日：2017-06-22

申请号：US15135928

申请日：2016-04-22

申请人： Paul B. Savage , Saurabh Shashikant Chitre , Kunal Arvind Varia , Hayley Ann Reece , Thomas E. Jacks , Ross A. Miller , Jared Lynn Randall

发明人： Paul B. Savage , Saurabh Shashikant Chitre , Kunal Arvind Varia , Hayley Ann Reece , Thomas E. Jacks , Ross A. Miller , Jared Lynn Randall

IPC分类号： C07J41/00 , C07C309/29 , C07C309/35

CPC分类号： C07J41/0088 , C07B2200/13 , C07C309/29 , C07C309/35 , C07J41/0061

摘要： Disclosed herein are acid addition salts of cationic steroidal antimicrobials (“CSAs” or “ceragenins”) and methods of making the same. Particularly advantageous salt forms are identified, such as 1,5-naphthalenedisulfonic acid addition salts and sulfate addition salts. The acid addition salts may be formulated for treating subjects with ailments responsive to CSAs, including but not limited to treating bacterial infections. Accordingly, some embodiments include formulations and methods of administering acid addition salts of CSAs.

2.

发明申请
CATIONIC STEROIDAL ANTIMICROBIAL SALTS 审中-公开
标题翻译：阳离子灭菌抗菌素

公开(公告)号：US20160311850A1

公开(公告)日：2016-10-27

申请号：US15135928

申请日：2016-04-22

申请人： Paul B. Savage , Saurabh Shashikant Chitre , Kunal Arvind Varia , Hayley Ann Reece , Thomas E. Jacks , Ross A. Miller , Jared Lynn Randall

发明人： Paul B. Savage , Saurabh Shashikant Chitre , Kunal Arvind Varia , Hayley Ann Reece , Thomas E. Jacks , Ross A. Miller , Jared Lynn Randall

IPC分类号： C07J41/00 , C07C309/29 , C07C309/35

CPC分类号： C07J41/0088 , C07B2200/13 , C07C309/29 , C07C309/35 , C07J41/0061

摘要： Disclosed herein are acid addition salts of cationic steroidal antimicrobials (“CSAs” or “ceragenins”) and methods of making the same. Particularly advantageous salt forms are identified, such as 1,5-naphthalenedisulfonic acid addition salts and sulfate addition salts. The acid addition salts may be formulated for treating subjects with ailments responsive to CSAs, including but not limited to treating bacterial infections. Accordingly, some embodiments include formulations and methods of administering acid addition salts of CSAs.

摘要翻译： 本文公开了阳离子甾族抗微生物剂（“CSA”或“ceragenins”）的酸加成盐及其制备方法。确定了特别有利的盐形式，例如1,5-萘二磺酸加成盐和硫酸盐加成盐。可以将酸加成盐配制用于治疗对CSA有反应性疾病的受试者，包括但不限于治疗细菌感染。因此，一些实施方案包括施用CSA的酸加成盐的制剂和方法。