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1.发明申请Tissue Density Quantification Using Shear Wave Information in Medical Ultrasound Scanning 有权医学超声扫描中使用剪切波信息的组织密度定量公开(公告)号：US20120108968A1
公开(公告)日：2012-05-03
申请号：US12913599
申请日：2010-10-27
申请人： Paul Freiburger , Liexiang Fan , Roee Lazebnik
发明人： Paul Freiburger , Liexiang Fan , Roee Lazebnik
IPC分类号： A61B8/00
CPC分类号： A61B8/0825 , A61B8/485 , A61B8/5223 , G01S7/52042
摘要： Tissue density is quantified using shear wave information in medical ultrasound scanning. Measurements of the tissue reaction to shear waves indicate tissue density. For example, shear wave velocity is linked with density using clinical study information. The shear wave velocity in a region, over the entire tissue, or at various locations is used to determine a corresponding density or densities. The tissue density information is used for categorization, estimation of disease risk, imaging, diagnosis, or other uses. The tissue may be breast tissue or other tissue.
摘要翻译： 在医学超声扫描中使用剪切波信息量化组织密度。 对剪切波的组织反应的测量表明组织密度。 例如，使用临床研究信息，剪切波速度与密度相关。 使用在整个组织或各个位置的区域中的剪切波速度来确定相应的密度或密度。 组织密度信息用于分类，估计疾病风险，成像，诊断或其他用途。 组织可以是乳房组织或其他组织。
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2.发明授权公开(公告)号：US10004474B2
公开(公告)日：2018-06-26
申请号：US12913599
申请日：2010-10-27
申请人： Paul Freiburger , Liexiang Fan , Roee Lazebnik
发明人： Paul Freiburger , Liexiang Fan , Roee Lazebnik
CPC分类号： A61B8/0825 , A61B8/485 , A61B8/5223 , G01S7/52042 , G06T7/0012 , G06T7/10
摘要： Tissue density is quantified using shear wave information in medical ultrasound scanning. Measurements of the tissue reaction to shear waves indicate tissue density. For example, shear wave velocity is linked with density using clinical study information. The shear wave velocity in a region, over the entire tissue, or at various locations is used to determine a corresponding density or densities. The tissue density information is used for categorization, estimation of disease risk, imaging, diagnosis, or other uses. The tissue may be breast tissue or other tissue.
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公开(公告)号：US20090005682A1
公开(公告)日：2009-01-01
申请号：US11824388
申请日：2007-06-28
申请人： Liexiang Fan , Paul Freiburger
发明人： Liexiang Fan , Paul Freiburger
摘要： Complex response of tissue is calculated as function of a convolution relationship associated with measured strain with applied stress. In the Fourier or frequency domain, the convolution is a simple algebraic computation, such as multiplication. The complex response provides elasticity and viscosity information, assisting diagnosis. Complex compliance may be directly calculated from the strain and stress. Complex fluidity may be directly calculated from strain rate and stress.
摘要翻译： 计算组织的复杂响应作为与所施加的应力的测量应变相关联的卷积关系的函数。 在傅立叶或频域中，卷积是一个简单的代数计算，如乘法。 复杂的反应提供弹性和粘度信息，辅助诊断。 复杂的顺应性可以从应变和应力直接计算。 复杂流动性可以从应变率和应力直接计算。
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公开(公告)号：US20100016718A1
公开(公告)日：2010-01-21
申请号：US12174011
申请日：2008-07-16
IPC分类号： A61B8/00
CPC分类号： A61B8/00 , A61B8/463 , A61B8/485 , G01S7/52042
摘要： Shear wave imaging is provided in medical diagnostic ultrasound. A region is imaged to determine a location in which to calculate shear velocity. The shear velocity is estimated for the location. The imaging may guide the identification of the location, reducing the time to determine useful shear information. The estimate of shear may be validated, such as using cross-validation, to indicate the confidence level of the shear value. The shear velocity may be displayed relative to a scale of shear velocities associated with a type of tissue, such as tissue for an organ. The location on a scale may be more intuitive for a user.
摘要翻译： 医学诊断超声波提供剪切波成像。 成像一个区域以确定计算剪切速度的位置。 估计剪切速度的位置。 成像可以指导位置的识别，减少确定有用剪切信息的时间。 可以验证剪切的估计，例如使用交叉验证来指示剪切值的置信水平。 剪切速度可以相对于与一种类型的组织（例如器官的组织）相关联的剪切速度的尺度显示。 比例尺上的位置对用户来说可能更直观。
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公开(公告)号：US10338203B2
公开(公告)日：2019-07-02
申请号：US13229408
申请日：2011-09-09
申请人： Liexiang Fan , Paul Freiburger , John Benson
发明人： Liexiang Fan , Paul Freiburger , John Benson
摘要： Classification preprocessing is provided for medical ultrasound shear wave imaging. In response to stress, the displacement at one or more locations in a patient is measured. The displacement over time is a curve representing a shift in location. One or more characteristics of the curve, such as signal-to-noise ratio and maximum displacement, are used to classify the location. The location is classified as fluid or fluid tissue, solid tissue, or non-determinative. Subsequent shear imaging may provide shear information for locations of solid tissue and not at other locations.
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公开(公告)号：US20130066204A1
公开(公告)日：2013-03-14
申请号：US13229408
申请日：2011-09-09
申请人： Liexiang Fan , Paul Freiburger , John Benson
发明人： Liexiang Fan , Paul Freiburger , John Benson
IPC分类号： A61B8/00
CPC分类号： G01S7/52036 , A61B8/0858 , A61B8/14 , A61B8/485 , A61B8/5207 , A61B8/5223 , G01S7/52022 , G03B42/06
摘要： Classification preprocessing is provided for medical ultrasound shear wave imaging. In response to stress, the displacement at one or more locations in a patient is measured. The displacement over time is a curve representing a shift in location. One or more characteristics of the curve, such as signal-to-noise ratio and maximum displacement, are used to classify the location. The location is classified as fluid or fluid tissue, solid tissue, or non-determinative. Subsequent shear imaging may provide shear information for locations of solid tissue and not at other locations.
摘要翻译： 为医学超声剪切波成像提供分类预处理。 响应于应力，测量患者中一个或多个位置处的位移。 时间上的位移是表示位置偏移的曲线。 使用曲线的一个或多个特征，例如信噪比和最大位移，用于对位置进行分类。 该位置被分类为流体或流体组织，固体组织或非决定性的。 随后的剪切成像可以为固体组织的位置提供剪切信息，而不是在其他位置。
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公开(公告)号：US08187187B2
公开(公告)日：2012-05-29
申请号：US12174011
申请日：2008-07-16
IPC分类号： A61B8/00
CPC分类号： A61B8/00 , A61B8/463 , A61B8/485 , G01S7/52042
摘要： Shear wave imaging is provided in medical diagnostic ultrasound. A region is imaged to determine a location in which to calculate shear velocity. The shear velocity is estimated for the location. The imaging may guide the identification of the location, reducing the time to determine useful shear information. The estimate of shear may be validated, such as using cross-validation, to indicate the confidence level of the shear value. The shear velocity may be displayed relative to a scale of shear velocities associated with a type of tissue, such as tissue for an organ. The location on a scale may be more intuitive for a user.
摘要翻译： 医学诊断超声波提供剪切波成像。 成像一个区域以确定计算剪切速度的位置。 估计剪切速度的位置。 成像可以指导位置的识别，减少确定有用剪切信息的时间。 可以验证剪切的估计，例如使用交叉验证来指示剪切值的置信水平。 剪切速度可以相对于与一种类型的组织（例如器官的组织）相关联的剪切速度的尺度显示。 比例尺上的位置对用户来说可能更直观。
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公开(公告)号：US08197408B2
公开(公告)日：2012-06-12
申请号：US12038683
申请日：2008-02-27
申请人： Liexiang Fan , Paul Freiburger
发明人： Liexiang Fan , Paul Freiburger
IPC分类号： A61B8/00
CPC分类号： G08C23/02 , A61B5/0048 , A61B8/08 , A61B8/485 , G01N3/24 , G01N2203/0089 , G01N2203/0094 , G01N2203/0623
摘要： The shear modulus information is measured for sparse locations in a scanning field of view. For other locations, the shear modulus information is calculated as a function of the sparsely measured values and strain information. For example, shear modulus values are provided for every grid point in a field of view based on strain values for every grid point and on sparsely measured shear modulus values.
摘要翻译： 在扫描视野中对稀疏位置测量剪切模量信息。 对于其他位置，剪切模量信息被计算为稀疏测量值和应变信息的函数。 例如，基于每个网格点的应变值和稀疏测量的剪切模量值，为视场中的每个网格点提供剪切模量值。
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公开(公告)号：US08137275B2
公开(公告)日：2012-03-20
申请号：US11824388
申请日：2007-06-28
申请人： Liexiang Fan , Paul Freiburger
发明人： Liexiang Fan , Paul Freiburger
IPC分类号： A61B8/00
摘要： Complex response of tissue is calculated as function of a convolution relationship associated with measured strain with applied stress. In the Fourier or frequency domain, the convolution is a simple algebraic computation, such as multiplication. The complex response provides elasticity and viscosity information, assisting diagnosis. Complex compliance may be directly calculated from the strain and stress. Complex fluidity may be directly calculated from strain rate and stress.
摘要翻译： 计算组织的复杂反应作为与所施加的应力的测量应变相关的卷积关系的函数。 在傅立叶或频域中，卷积是一个简单的代数计算，如乘法。 复杂的反应提供弹性和粘度信息，辅助诊断。 复杂的顺应性可以从应变和应力直接计算。 复杂流动性可以从应变率和应力直接计算。
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10.发明申请Measuring transducer movement methods and systems for multi-dimensional ultrasound imaging 失效用于多维超声成像的测量传感器移动方法和系统公开(公告)号：US20070043293A1
公开(公告)日：2007-02-22
申请号：US11590569
申请日：2006-10-30
IPC分类号： A61B8/00
CPC分类号： A61B8/4254 , A61B8/00 , A61B8/483
摘要： Methods and systems for measuring transducer movement are provided. For example, free-hand scanning for three-dimensional imaging is provided. An optical sensor within the transducer measures motion along the skin surface similar to measuring movement of a personal computer mouse with an optical sensor. Alternatively or additionally, the transducer is tilted at an angle other than perpendicular to the skin surface generally towards or away from the direction in which the transducer is translated. The transducer is then translated while maintaining the angle. Motion to or from the transducer is measured, and a component of the motion measured while the transducer is maintained at an angle is parallel to the direction of translation. The component of motion is angle corrected and used to determine a distance of travel.
摘要翻译： 提供了测量传感器运动的方法和系统。 例如，提供用于三维成像的自由扫描。 换能器内的光学传感器测量皮肤表面的运动，类似于使用光学传感器测量个人计算机鼠标的移动。 或者或另外，换能器以与换能器平移方向大致相反或远离换能器方向的角度倾斜，而不是垂直于皮肤表面。 然后在保持角度的同时平移换能器。 测量与传感器的运动，并且在换能器保持一定角度时测量的运动的分量平行于平移方向。 运动的分量被角度校正，用于确定行驶距离。
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