公开(公告)号：US20080058560A1

公开(公告)日：2008-03-06

申请号：US10599472

申请日：2005-02-04

申请人： Paul Massell ,  Joel Swinson ,  Barry Jones ,  Daniel Graham

发明人： Paul Massell ,  Joel Swinson ,  Barry Jones ,  Daniel Graham

IPC分类号： C07C29/132 ,  C07C29/74

CPC分类号： C07C29/145 ,  C07C29/76 ,  C07C29/80 ,  C07C31/38

摘要： 1,1,1,3,3,3-Hexafluoroisopropanol (HFIP) substantially free of 1,1,1-trifluoroacetone (TFA) can be separated from a mixture containing both compounds by A) catalytic reduction with hydrogen followed by fractional distillation; B) cooling to a temperature at which HFIP freezes and TFA remains liquid; C) forming a high boiling complex comprising HF and TFA followed by fractional distillation; or D) producing HF-free conditions to yield a HFIP/TFA azeotrope followed by fractional distillation. It is emphasized that this abstract is provided to comply with the rules requiring an abstract, which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims. 37 CFR § 1.72(b).

摘要翻译： 基本上不含1,1,1-三氟丙酮（TFA）的1,1,1,3,3,3-六氟异丙醇（HFIP）可以从含有这两种化合物的混合物中分离出来，A）用氢气催化还原，然后分馏; B）冷却至HFIP冻结的温度，TFA保持液态; C）形成包含HF和TFA的高沸点络合物，然后分馏; 或D）产生无HF条件以产生HFIP / TFA共沸物，随后进行分馏。 要强调的是，该摘要被提供以符合要求摘要的规则，这将允许搜索者或其他读者快速确定技术公开的主题。 提交它的理解是，它不会用于解释或限制权利要求的范围或含义。 37 CFR§1.72（b）。

公开(公告)号：US07659433B2

公开(公告)日：2010-02-09

申请号：US10599472

申请日：2005-02-04

申请人： Paul Mazzell, Jr. ,  Joel Swinson ,  Barry Jones ,  Daniel Graham

发明人： Paul Mazzell, Jr. ,  Joel Swinson ,  Barry Jones ,  Daniel Graham

IPC分类号： C07C29/145 ,  C07C29/82 ,  C07C29/80

CPC分类号： C07C29/145 ,  C07C29/76 ,  C07C29/80 ,  C07C31/38

摘要： 1,1,1,3,3,3-Hexafluoroisopropanol (HFIP) substantially free of 1,1,1-trifluoroacetone (TFA) can be separated from a mixture containing both compounds by A) catalytic reduction with hydrogen followed by fractional distillation; B) cooling to a temperature at which HFIP freezes and TFA remains liquid; C) forming a high boiling complex comprising HF and TFA followed by fractional distillation; or D) producing HF-free conditions to yield a HFIP/TFA azeotrope followed by fractional distillation. It is emphasized that this abstract is provided to comply with the rules requiring an abstract, which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims. 37 CFR § 1.72(b).

摘要翻译： 基本上不含1,1,1-三氟丙酮（TFA）的1,1,1,3,3,3-六氟异丙醇（HFIP）可以从含有这两种化合物的混合物中分离出来，A）用氢气催化还原，然后分馏; B）冷却至HFIP冻结的温度，TFA保持液态; C）形成包含HF和TFA的高沸点络合物，然后分馏; 或D）产生无HF条件以产生HFIP / TFA共沸物，随后进行分馏。 要强调的是，该摘要被提供以符合要求摘要的规则，这将允许搜索者或其他读者快速确定技术公开的主题。 提交它的理解是，它不会用于解释或限制权利要求的范围或含义。 37 CFR§1.72（b）。

公开(公告)号：US20240092115A1

公开(公告)日：2024-03-21

申请号：US18369398

申请日：2023-09-18

申请人： Daniel Graham

发明人： Daniel Graham

IPC分类号： B42F9/00

CPC分类号： B42F9/002

摘要： A clipboard with fold-out, extendable legs. This allows the user to set the extended legs on the floor leaving the clipboard standing in a horizontal position at a convenient hip height. With this, the user has both hands free for the task and a practical, convenient place for the clipboard to rest. With the legs in the extended position, it is strong enough to write on and light enough to pick up and move to a new location

公开(公告)号：US20090186160A1

公开(公告)日：2009-07-23

申请号：US12355397

申请日：2009-01-16

申请人： Christopher D. Timmons ,  Drew E. Johansson ,  Daniel Graham

发明人： Christopher D. Timmons ,  Drew E. Johansson ,  Daniel Graham

IPC分类号： B05D1/02 ,  B05D1/18 ,  C09D5/00

CPC分类号： B05D1/185 ,  B82Y30/00 ,  B82Y40/00 ,  C03C17/003 ,  C03C17/30 ,  C09D4/00 ,  C08G77/04

摘要： There is disclosed a coating matrix of an extremely thin or monolayer coating for glass or other beverage packaging surfaces. More specifically, there is disclosed materials that can be used to improve the shelf life of packaged materials, such as bottled beer. More specifically, there is disclosed an anti-oxidation coating comprising a cross-linked monolayer that has a hydrophobic character and bound to beverage packaging surface through surface hydroxyl groups and a silane moiety. Moreover, there is disclosed a metal ion chelating moiety as part of the coating matrix.

摘要翻译： 公开了一种用于玻璃或其它饮料包装表面的极薄或单层涂层的涂层基质。 更具体地，公开了可用于提高包装材料如瓶装啤酒的保质期的材料。 更具体地，公开了一种抗氧化涂层，其包含具有疏水性质的交联单层，并通过表面羟基和硅烷部分与饮料包装表面结合。 此外，公开了金属离子螯合部分作为涂层基质的一部分。

公开(公告)号：US5776765A

公开(公告)日：1998-07-07

申请号：US569083

申请日：1995-12-18

申请人： Daniel Graham ,  Robert Holt ,  Per Lindberg ,  Stephen Taylor

发明人： Daniel Graham ,  Robert Holt ,  Per Lindberg ,  Stephen Taylor

IPC分类号： C12P41/00 ,  A61K31/44 ,  A61K31/4427 ,  A61P1/04 ,  C07D401/12 ,  C12P17/18 ,  C12R1/19 ,  C12R1/37 ,  C12P11/00

CPC分类号： C07D401/12 ,  C12P17/182 ,  C12P17/185 ,  Y10S435/822 ,  Y10S435/849 ,  Y10S435/873

摘要： A compound of formula (II), either as a single enantiomer or in an enantiomerically enriched form ##STR1## wherein: ##STR2## and ##STR3## (wherein N in the benzimidazole moiety of Het.sub.2 means that one of the carbon atoms substituted by any one of R.sub.6 to R.sub.9 optionally may be exchanged for an unsubstituted nitrogen atom; R.sub.1, R.sub.2 and R.sub.3 are the same or different and selected from hydrogen, alkyl, alkoxy optionally substituted by fluorine, alkylthio, alkoxyalkoxy, dialkylamino, piperidino, morpholino, halogen, phenylalkyl, phenylakoxy; R.sub.4 and R.sub.4, are the same or different and selected from hydrogen, alkyl, aralkyl; R.sub.5 is hydrogen, halogen, trifluoromethyl, alkyl, alkoxy; R.sub.6 -R.sub.9 are the same or different and selected from hydrogen, alkyl, alkoxy, halogen, haloalkoxy, alkylcarbonyl, alkoxycarbonyl, oxazolyl, trifluoroalkyl or adjacent groups R.sub.6 -R.sub.9 may complete together with the carbon atoms to which they are attached optionally substituted ring structures; R.sub.10 is hydrogen or alkoxycarbonyloxymethyl; R.sub.11 is hydrogen or forms an alkylene chain together with R.sub.3 ; R.sub.12 and R.sub.13 are the same or different and selected from hydrogen, halogen or alkyl) is obtained by stereoselective bioreduction of a compound of formula (II) in racemic form.

摘要翻译： PCT No.PCT / SE95 / 01416 Sec。 371 1995年12月18日第 102（e）1995年12月18日PCT PCT 1995年11月27日提交的式（II）化合物作为单一对映异构体或以对映异构体富集形式（II），其中：＆lt; IMAGE＆gt;和＆lt; IMAGE＆ （其中Het2的苯并咪唑部分中的N表示被R6至R9中任一个取代的碳原子之一任选地可以被替换为未取代的氮原子; R 1，R 2和R 3相同或不同，并且选自 氢，烷基，任选被氟取代的烷氧基，烷硫基，烷氧基烷氧基，二烷基氨基，哌啶子基，吗啉代，卤素，苯基烷基，苯基烷氧基; R4和R4相同或不同，选自氢，烷基，芳烷基; R5是氢， 三氟甲基，烷基，烷氧基; R6 -R9相同或不同，选自氢，烷基，烷氧基，卤素，卤代烷氧基，烷基羰基，烷氧基羰基，恶唑基，三氟烷基或相邻基团R6 -R9可以与它们 任选地替换 环形结构; R 10是氢或烷氧基羰氧基甲基; R 11是氢或与R 3一起形成亚烷基链; R 12和R 13相同或不同，选自氢，卤素或烷基）通过外消旋形式的式（II）化合物的立体选择性生物还原获得。

公开(公告)号：US20200268736A1

公开(公告)日：2020-08-27

申请号：US16651163

申请日：2018-09-26

申请人： Elizaveta Leshchiner ,  Zhifang Cao ,  Jason Rush ,  Michael Durney ,  Alykhan Shamji ,  Daniel Graham ,  Stuart L. Schreiber ,  Ramnik Xavier

发明人： Elizaveta Leshchiner ,  Zhifang Cao ,  Jason Rush ,  Michael Durney ,  Alykhan Shamji ,  Daniel Graham ,  Stuart L. Schreiber ,  Ramnik Xavier

IPC分类号： A61K31/4545 ,  A61K31/496

摘要： Disclosed herein are compounds for the treatment of inflammatory bowel disease. Additionally, provided herein are compositions and methods for using these compounds and compositions in the treatment of inflammatory bowel disease in a subject.