公开(公告)号：US08283500B2

公开(公告)日：2012-10-09

申请号：US11815673

申请日：2006-02-09

申请人： Paul Mazzell ,  Barry Jones ,  Neville Pavri ,  Joel Swinson

发明人： Paul Mazzell ,  Barry Jones ,  Neville Pavri ,  Joel Swinson

IPC分类号： C07C43/00

CPC分类号： C07C41/40 ,  C07C41/38 ,  C07C41/42 ,  C07C43/123

摘要： An azeotrope comprising desflurane (CF3CFHOCF2H) and hydrogen fluoride (HF). The azeotrope can be prepared by fractionally distilling a crude mixture of desflurane and HF. Purer desflurane can be readily and easily separated from the azeotrope. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader quickly to ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the appended issued claims.

摘要翻译： 包含地氟烷（CF 3 CFHOCF 2 H）和氟化氢（HF）的共沸物。 可以通过分馏蒸馏地氟烷和HF的粗混合物来制备共沸物。 Purer地氟烷可以容易地和容易地从共沸物中分离出来。 要强调的是，该摘要被提供以符合要求抽象的规则，这将允许搜索者或其他读者快速地确定技术公开的主题。 提交它的理解是，它不会用于解释或限制所附权利要求的范围或含义。

公开(公告)号：US20080306309A1

公开(公告)日：2008-12-11

申请号：US11815673

申请日：2006-02-09

申请人： Paul Mazzell ,  Barry Jones ,  Neville Pavri ,  Joel Swinson

发明人： Paul Mazzell ,  Barry Jones ,  Neville Pavri ,  Joel Swinson

IPC分类号： C07C41/42 ,  C09K3/00

CPC分类号： C07C41/40 ,  C07C41/38 ,  C07C41/42 ,  C07C43/123

摘要： An azeotrope comprising desflurane (CF3CFHOCF2H) and hydrogen fluoride (HF). The azeotrope can be prepared by fractionally distilling a crude mixture of desflurane and HF. Purer desflurane can be readily and easily separated from the azeotrope. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader quickly to ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the appended issued claims.

摘要翻译： 包含地氟烷（CF 3 CFHOCF 2 H）和氟化氢（HF）的共沸物。 可以通过分馏蒸馏地氟烷和HF的粗混合物来制备共沸物。 Purer地氟烷可以容易地和容易地从共沸物中分离出来。 要强调的是，该摘要被提供以符合要求抽象的规则，这将允许搜索者或其他读者快速地确定技术公开的主题。 提交它的理解是，它不会用于解释或限制所附权利要求的范围或含义。

公开(公告)号：US20090171128A1

公开(公告)日：2009-07-02

申请号：US11965137

申请日：2007-12-27

申请人： Barry Jones ,  Joel Swinson ,  Paul Mazzell

发明人： Barry Jones ,  Joel Swinson ,  Paul Mazzell

IPC分类号： C07C41/38

CPC分类号： C07C41/01 ,  C07C41/38 ,  Y02P20/127 ,  C07C43/123

摘要： A process for purifying crude fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (sevoflurane). The crude sevoflurane is repeatedly washed with water under conditions and for a time sufficient to reduce the level of 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) to no more than 200 ppm or no more than 100 ppm.

摘要翻译： 粗氟甲基1,1,1,3,3,3-六氟异丙醚（七氟醚）的纯化方法。 在足以将1,1,1,3,3,3-六氟异丙醇（HFIP）的水平降低至不大于200ppm或不超过100ppm的条件下，用水重复洗涤粗制七氟醚。

公开(公告)号：US07732647B2

公开(公告)日：2010-06-08

申请号：US11965137

申请日：2007-12-27

申请人： Barry Jones ,  Joel Swinson ,  Paul Mazzell

发明人： Barry Jones ,  Joel Swinson ,  Paul Mazzell

IPC分类号： C07C41/38

CPC分类号： C07C41/01 ,  C07C41/38 ,  Y02P20/127 ,  C07C43/123

摘要： A process for purifying crude fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (sevoflurane). The crude sevoflurane is repeatedly washed with water under conditions and for a time sufficient to reduce the level of 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) to no more than 200 ppm or no more than 100 ppm.

摘要翻译： 粗氟甲基1,1,1,3,3,3-六氟异丙醚（七氟醚）的纯化方法。 在足以将1,1,1,3,3,3-六氟异丙醇（HFIP）的水平降低至不大于200ppm或不超过100ppm的条件下，用水重复洗涤粗制七氟醚。

公开(公告)号：US20090275785A1

公开(公告)日：2009-11-05

申请号：US12113655

申请日：2008-05-01

申请人： Barry Jones ,  Joel Swinson ,  Paul Mazzell

发明人： Barry Jones ,  Joel Swinson ,  Paul Mazzell

IPC分类号： C07C41/42 ,  B08B3/08

CPC分类号： C07C41/42 ,  C07C43/123

摘要： Processes for preparing commercial quantities of a stable, pharmaceutically acceptable sevoflurane substantially tree of impurities are claimed. In another embodiment, a process for removing reactive metal, salts from the surface of metallic equipment used in the distillation of sevoflurane and rendering a non-inert metallic surface of the metallic equipment inert.

摘要翻译： 要求用于制备商业量的稳定的药学上可接受的七氟烷基本上杂质树的方法。 在另一个实施方案中，从用于蒸馏七氟醚的金属设备的表面除去活性金属盐，并使金属设备的非惰性金属表面呈惰性的方法。

公开(公告)号：US20100280283A1

公开(公告)日：2010-11-04

申请号：US12833676

申请日：2010-07-09

申请人： Barry Jones ,  Joel Swinson ,  Paul Mazzell

发明人： Barry Jones ,  Joel Swinson ,  Paul Mazzell

IPC分类号： C07C41/42

CPC分类号： C07C41/42 ,  C07C43/123

摘要： Processes for preparing commercial quantities of a stable, pharmaceutically acceptable sevoflurane substantially free of impurities are claimed. In another embodiment, a process for removing reactive metal salts from the surface of metallic equipment used in the distillation of sevoflurane and rendering a non-inert metallic surface of the metallic equipment inert.

摘要翻译： 要求制备商业量的基本上不含杂质的稳定的药学上可接受的七氟醚的方法。 在另一个实施方案中，从用于蒸馏七氟醚的金属设备的表面除去活性金属盐并使金属设备的非惰性金属表面呈惰性的方法。

公开(公告)号：USH2211H1

公开(公告)日：2008-03-04

申请号：US11687774

申请日：2007-03-19

申请人： Neville Pavri ,  Danny Graham ,  Mark Harris ,  Paul Mazzell

发明人： Neville Pavri ,  Danny Graham ,  Mark Harris ,  Paul Mazzell

IPC分类号： C07C45/86

摘要： Fluorinated ketones, for example, 1,1,1-trifluoroacetone, can be stabilized against storage degradation by combining with a content of hexafluoroisopropanol (HFIP). Containers containing the stabilized mixture show prolonged storage times compared to containers containing the fluorinated ketones alone. The stabilized mixture can be used as a starting material for reactions requiring fluorinated ketones, for example, 1,1,1-trifluoroacetone, as a starting material.

公开(公告)号：USH2234H1

公开(公告)日：2010-01-05

申请号：US11400453

申请日：2006-04-07

申请人： Paul Mazzell ,  Peter Murin

发明人： Paul Mazzell ,  Peter Murin

IPC分类号： A61M15/00

摘要： A process for preparing 2-difluoromethoxy-1,1,1,2-tetrafluoroethane (desflurane) comprising the following steps: (a) providing a first mixture comprising desflurane and 2,2-dichloro-1,1,1-trifluoroethane (R-123); (b) adding water to the first mixture to form a second mixture; and (c) fractionally distilling the second mixture to yield a desflurane product purer in R-123 than said the mixture. Also described is a purified desflurane product prepared by the process, and intermediate products comprising water added to a mixture of desflurane and R-123.