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公开(公告)号：US20100004321A1
公开(公告)日：2010-01-07
申请号：US12308796
申请日：2007-06-29
申请人： Paul Ross , Aidan Coffey
发明人： Paul Ross , Aidan Coffey
摘要： The present invention provides a plasmid pSOFLysK contained in the bacterial strain Lactococcus lactis NZ9800 referred herein as Lactococcus lactis NZ9800-pSOFLysK (subsequently designated Lactococcus lactis DPC6132) encoding anti-staphylococcal activity as deposited with DSMZ under accession No. ncimb 41409 and plasmids substantially similar thereto also providing anti-staphylococcal activity. In another aspect, the present invention provides a gene encoding an anti-staphylococcal protein, Lysin (LysK) as encoded by the plasmid pSOFLysK in Lactococcus lactis/VZ9800-pSOFLysK (subsequently designated Lactococcus lactis DPC6132). The recombinant lysine also has applications in diagnostics given its lytic mechanism.
摘要翻译： 本发明提供了包含在乳酸乳球菌乳球菌NZ9800中的质粒pSOFLysK，其称为乳酸乳球菌NZ9800-pSOFLysK（随后命名为乳酸乳球菌乳球菌DPC6132），其编码抗性葡萄球菌活性，保藏号为ncimb 41409的DSMZ和与其基本相似的质粒 也提供抗葡萄球菌活性。 另一方面，本发明提供编码由乳酸乳球菌/ VZ9800-pSOFLysK（随后称为乳酸乳球菌DPC6132）中质粒pSOFLysK编码的抗葡萄球菌蛋白的赖氨酸（LysK）的基因。 重组赖氨酸还具有其诊断机制的诊断应用。
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公开(公告)号：US5019506A
公开(公告)日：1991-05-28
申请号：US242259
申请日：1988-09-08
申请人： Charles Daly , Gerald F. Fitzgerald , Aidan Coffey , Veronica A. Costello , Maeve C. Murphy , Andreas Baumgartner
发明人： Charles Daly , Gerald F. Fitzgerald , Aidan Coffey , Veronica A. Costello , Maeve C. Murphy , Andreas Baumgartner
IPC分类号： C07K14/315 , C12N1/21
CPC分类号： C07K14/315
摘要： Plasmids carrying one or more genes which confer phage insensitivity upon Streptococcus lactis or Streptococcus lactis subsp. diacetylactis as well as Streptococcus cremoris bacteria in which the insensitivity is not destroyed at temperatures of up to 40.degree. C. are described. DNA fragments are also described which encode phage insensitivity. Such plasmids and DNA fragments are suitable for conferring phage insensitivity upon bacteria or food starter cultures containing bacteria.
摘要翻译： 携带一种或多种赋予乳链球菌或乳链球菌亚种的噬菌体不敏感的基因的质粒。 描述了在高达40℃的温度下不破坏不敏感性的二乙酰乳杆菌以及乳链球菌（Streptococcus cremoris）。 还描述了编码噬菌体不敏感性的DNA片段。 这样的质粒和DNA片段适合于赋予细菌或包含细菌的食物发酵剂培养物不敏感的噬菌体。
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