公开(公告)号：US20050055072A1

公开(公告)日：2005-03-10

申请号：US10942353

申请日：2004-09-15

申请人： Paul Rubery ,  Edward Schwarz

发明人： Paul Rubery ,  Edward Schwarz

IPC分类号： A61K48/00 ,  C12N15/864 ,  A61N5/06

CPC分类号： C12N15/86 ,  A61K48/00 ,  A61K48/0008 ,  A61K48/0083 ,  C12N2750/14143

摘要： In accordance with the present invention, methods and structures are provided for the treatment of functional spinal unit injuries through the use of light activated gene therapy to induce bone fusion through the introduction of a desired gene into a patient's spinal tissue. Methods and structures are also provided for the utilization of ultraviolet light activated gene therapy to repair/rebuild an injured intervertebral disc through the introduction of a desired gene into a patient's spinal tissue. An implant system including a light probe and an implant with which r-AAV is integrated is also provided.

摘要翻译： 根据本发明，提供了通过使用光激活基因治疗通过将期望的基因引入患者的脊髓组织来诱导骨融合来治疗功能性脊柱单位损伤的方法和结构。 还提供了方法和结构，以利用紫外线激活基因治疗来通过将期望的基因引入患者的脊髓组织来修复/重建损伤的椎间盘。 还提供了一种植入系统，其包括光探针和与其一体化的r-AAV的植入物。