公开(公告)号：US07531505B2

公开(公告)日：2009-05-12

申请号：US11649935

申请日：2007-01-05

申请人： Paul Theodore Hamilton ,  Daniel James Kenan ,  Amy Katherine Solan

发明人： Paul Theodore Hamilton ,  Daniel James Kenan ,  Amy Katherine Solan

IPC分类号： A61K38/00 ,  A61F2/04

CPC分类号： C07K14/705 ,  A61K38/00 ,  A61L27/34 ,  A61L31/10 ,  C07K7/06 ,  C07K7/08 ,  C07K2319/00

摘要： The present invention provides compositions and methods for an improved coating for medical devices. Provided is a biofunctional coating composition comprising at least one binding domain that has binding specificity for a metallic surface material of a medical device, and at least one binding domain that has binding specificity for cells of endothelial cell lineage. Methods for coating a metallic surface of a medical device, and for manufacturing of a medical device, comprise contacting the metallic surface to be coated with the biofunctional coating material in an amount effective to form a coating, and may further comprise contacting the coated surface with cells of endothelial cell lineage to bind the cells of endothelial cell lineage to the coated surface.

摘要翻译： 本发明提供用于医疗装置的改进涂层的组合物和方法。 本发明提供一种生物功能性涂料组合物，其包含至少一个对医疗器械的金属表面材料具有结合特异性的结合结构域和至少一个对内皮细胞谱系细胞具有结合特异性的结合结构域。 用于涂覆医疗装置的金属表面和用于制造医疗装置的方法包括以有效形成涂层的量使待涂覆的金属表面与生物功能性涂层接触，并且还可以包括使涂覆的表面与 内皮细胞谱系的细胞将内皮细胞谱系的细胞结合到包被的表面。