公开(公告)号：US08563599B2

公开(公告)日：2013-10-22

申请号：US12921013

申请日：2009-03-03

申请人： Paul W. Erhardt ,  Rahul Khupse ,  Jefferey G. Sarver ,  Thomas E. Cleveland ,  Stephen M. Boue ,  Thomas E. Wiese ,  Matthew E. Burow ,  John A. McLachlan

发明人： Paul W. Erhardt ,  Rahul Khupse ,  Jefferey G. Sarver ,  Thomas E. Cleveland ,  Stephen M. Boue ,  Thomas E. Wiese ,  Matthew E. Burow ,  John A. McLachlan

IPC分类号： A61K31/352

CPC分类号： C07D493/14

摘要： Two distinct methods are disclosed and claimed for synthesizing glyceollin I plus glyceollin II as a mixture and as their pure forms. Stereochemical isomers and various synthetic intermediates are also synthesized and claimed for their novel compositions of matter. All compounds and their mixtures are claimed for use in formulations that are useful to treat or prevent cancer, or that have utility as selective estrogen receptor modulators, such formulations including enhanced or medical foods, dietary supplements and ethical pharmaceutical agents.

摘要翻译： 公开和要求的两种不同的方法用于合成甘氨酸蛋白I加血糖素II作为混合物，并以其纯形式。 立体化学异构体和各种合成中间体也由它们的新物质组合物合成和要求保护。 要求所有化合物及其混合物用于可用于治疗或预防癌症或具有选择性雌激素受体调节剂的制剂的制剂中，所述制剂包括增强型或医用食品，膳食补充剂和伦理药剂。