MAGNETIC ROTATION TO IMPROVE SIGNAL-OVER-BACKGROUND IN BIOSENSING
    2.
    发明申请
    MAGNETIC ROTATION TO IMPROVE SIGNAL-OVER-BACKGROUND IN BIOSENSING 失效
    磁性旋转以提高生物传感中的信号

    公开(公告)号:US20070172890A1

    公开(公告)日:2007-07-26

    申请号:US11569084

    申请日:2005-05-13

    IPC分类号: G01N33/53 G01N33/551 C12M3/00

    摘要: The invention provides a method and a device (10) for distinguishing a specific binding from a less specific binding between at least one magnetic nanoparticle (11) and a surface of another entity by applying a magnetic field and detecting a physical parameter relating to magnetic nanoparticle rotational or motional freedom while the magnetic nanoparticle (11) is attached to the surface. The method and device (10) may be applied to in-vivo and in-vitro biomolecular diagnostics. The sensor (10) according to the present invention combines in one sensor (10) the detection of magnetic particles or labels (11) and determination of the binding quality and the properties of magnetic particles or labels (11) which are bound to the surface of another entity.

    摘要翻译: 本发明提供了一种方法和装置(10),用于通过施加磁场和检测与磁性纳米颗粒相关的物理参数来区分特定结合与至少一个磁性纳米颗粒(11)和另一个实体的表面之间的较小特异性结合 旋转或运动自由而磁性纳米颗粒(11)附着于表面。 方法和装置(10)可以应用于体内和体外生物分子诊断。 根据本发明的传感器(10)在一个传感器(10)中结合了磁性颗粒或标签(11)的检测以及结合质量的测定以及与表面结合的磁性颗粒或标签(11)的性质 的另一个实体。