公开(公告)号：US20190083450A1

公开(公告)日：2019-03-21

申请号：US16192117

申请日：2018-11-15

申请人： Pavel Dibrov ,  Elena Dibrov ,  Grant Pierce

发明人： Pavel Dibrov ,  Elena Dibrov ,  Grant Pierce

IPC分类号： A61K31/341 ,  A61K31/16 ,  C07F9/655 ,  A61K31/365 ,  C07D307/66 ,  C07D309/30

CPC分类号： A61K31/341 ,  A61K31/16 ,  A61K31/365 ,  A61K2300/00 ,  A61P31/04 ,  C07D307/66 ,  C07D309/30 ,  C07F9/655 ,  C07F9/65515 ,  Y02A50/406 ,  Y02A50/478 ,  Y02A50/483

摘要： An antibiotic compound of formula (III): or a salt or stereoisomer thereof; wherein R1-R3 and R5-R10 are independently selected from the group consisting of H, alkyl group, substituted alkyl group, halogen, OH, NH2 and SH; R4 is H, alkyl group or substituted alkyl group; X1-X2 are independently selected from the group consisting of ═O, ═S, NH, H, alkyl, halogen, OH, SH and NH2; W is a saturated acyclic hydrocarbon chain of 1 to 15 carbon atoms; and Z is a neutral or positively charged organic group. The compounds are useful in treating bacterial diseases.

公开(公告)号：US10744111B2

公开(公告)日：2020-08-18

申请号：US16192117

申请日：2018-11-15

申请人： Pavel Dibrov ,  Elena Dibrov ,  Grant Pierce

发明人： Pavel Dibrov ,  Elena Dibrov ,  Grant Pierce

IPC分类号： A61K31/341 ,  C07D307/66 ,  C07F9/655 ,  A61P31/04 ,  A61K31/16 ,  A61K31/365 ,  C07D309/30

摘要： An antibiotic compound of formula (III): or a salt or stereoisomer thereof; wherein R1-R3 and R5-R10 are independently selected from the group consisting of H, alkyl group, substituted alkyl group, halogen, OH, NH2 and SH; R4 is H, alkyl group or substituted alkyl group; X1-X2 are independently selected from the group consisting of ═O, ═S, NH, H, alkyl, halogen, OH, SH and NH2; W is a saturated acyclic hydrocarbon chain of 1 to 15 carbon atoms; and Z is a neutral or positively charged organic group. The compounds are useful in treating bacterial diseases.

公开(公告)号：US10166213B2

公开(公告)日：2019-01-01

申请号：US15500006

申请日：2016-04-22

申请人： Pavel Dibrov ,  Elena Dibrov ,  Grant Pierce

发明人： Pavel Dibrov ,  Elena Dibrov ,  Grant Pierce

IPC分类号： A61K31/341 ,  C07D307/66 ,  C07F9/655 ,  A61K31/365 ,  C07D309/30 ,  A61K31/16

摘要： An antibiotic compound is of formula (I): R1-R3, R5 and R6 are independently selected from H, alkyl group, substituted alkyl group, halogen, OH, NH2, or SH; R4 is H, alkyl group or substituted alkyl group. X1-X2 are independently selected from O, S, NH, H, alkyl, halogen, OH, SH, or NH2. Y is an acyclic hydrocarbon chain having 4 to 20 carbon atoms or a substituted acyclic hydrocarbon chain having 4 to 20 carbon atoms, but does not include an oxygen atom. Z is CH3 or any neutral or positively charged group. The compound can also be a salt or stereoisomer of formula (I). The compounds are useful in treating bacterial diseases.

公开(公告)号：US20180064680A1

公开(公告)日：2018-03-08

申请号：US15500006

申请日：2016-04-22

申请人： Pavel Dibrov ,  Elena Dibrov ,  Grant Pierce

发明人： Pavel Dibrov ,  Elena Dibrov ,  Grant Pierce

IPC分类号： A61K31/341 ,  A61K31/365 ,  A61K31/16 ,  C07D309/30 ,  C07F9/655

CPC分类号： A61K31/341 ,  A61K31/16 ,  A61K31/365 ,  A61K2300/00 ,  A61P31/04 ,  C07D307/66 ,  C07D309/30 ,  C07F9/655 ,  C07F9/65515 ,  Y02A50/406 ,  Y02A50/478 ,  Y02A50/483

摘要： An antibiotic compound is of formula (I): R1-R3, R5 and R6 are independently selected from H, alkyl group, substituted alkyl group, halogen, OH, NH2, or SH; R4 is H, alkyl group or substituted alkyl group. X1-X2 are independently selected from O, S, NH, H, alkyl, halogen, OH, SH, or NH2 Y is an acyclic hydrocarbon chain having 4 to 20 carbon atoms or a substituted acyclic hydrocarbon chain having 4 to 20 carbon atoms, but does not include an oxygen atom. Z is CH3 or any neutral or positively charged group. The compound can also be a salt or stereoisomer of formula (I). The compounds are useful in treating bacterial diseases.