公开(公告)号：US12297508B2

公开(公告)日：2025-05-13

申请号：US17960026

申请日：2022-10-04

Applicant: Personalis, Inc.

Inventor： John West ,  Laurie Goodman ,  Richard Chen

IPC: C12Q1/6886 ,  C12Q1/6827 ,  C12Q1/6874 ,  G16B30/10 ,  G16H10/40

Abstract: The present disclosure provides methods and systems for personalized genetic testing of disease in a subject, in particular for identifying and tracking genetic mutations identified in an individual subject to monitor for cancer or for the spread or recurrence of the disease. In some embodiments, custom assays, including custom panels designed to target sequence data corresponding to both subject-specific loci and other loci known for cancer-causing or therapy resistance mutations, are designed based upon the sequencing of a screening biopsy sample. Such custom assays are then run on subsequently obtained tissue samples, such as tissue obtained from a surgical resection of a primary or metastatic tumor or from a lymph node biopsy. The subsequently obtained tissue samples can be taken from the subject at various time points after an initial screening biopsy to further allow for extended monitoring of the subject for spread or recurrence of the disease.