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    SALTS OF (3-0-(3',3'-DIMETHYLSUCCINYL) BETULINIC ACID AND SOLID STATE FORMS THEREOF
    1.
    发明申请
    SALTS OF (3-0-(3',3'-DIMETHYLSUCCINYL) BETULINIC ACID AND SOLID STATE FORMS THEREOF 审中-公开
    （3-0-（3'，3'-二甲基氨基）乙酸和其固体状态的盐

    公开(公告)号：US20110224182A1

    公开(公告)日：2011-09-15

    申请号：US12504883

    申请日：2009-07-17

    申请人： Peter Bullock ,  Theodore J. Nitz ,  Gary Sweetapple

    发明人： Peter Bullock ,  Theodore J. Nitz ,  Gary Sweetapple

    IPC分类号： A61K31/56 ,  C07J53/00 ,  A61P31/18

    CPC分类号： C07J53/00

    摘要： The present invention concerns novel pharmaceutically active compounds, pharmaceutical compositions containing the same, methods of making the compounds, polymorphic forms of the compounds, the compounds for use as medicaments, and use of the compounds for the manufacture of medicaments. The present invention also concerns a method of treatment involving administration of the compounds. Specifically, the compounds are certain salts of 3-O-(3′,3′-dimethylsuccinyl)betulinic acid, also known as “DSB.” The novel compounds are useful as antiretroviral agents. In particular, the novel compounds are useful for the treatment of Human Immunodeficiency Virus (“HIV”).

    摘要翻译： 本发明涉及新颖的药物活性化合物，含有它们的药物组合物，制备化合物的方法，化合物的多晶型物，用作药物的化合物以及用于制备药物的化合物的用途。 本发明还涉及涉及给药化合物的治疗方法。 具体地说，这些化合物是3-O-（3'，3'-二甲基琥珀酰基）桦木酸的某些盐，也称为“DSB”。该新化合物可用作抗逆转录病毒剂。 特别地，新化合物可用于治疗人类免疫缺陷病毒（HIV）。