公开(公告)号：US20120230955A1

公开(公告)日：2012-09-13

申请号：US13059293

申请日：2009-08-18

申请人： Peter Frank Ekhart ,  Hans Van De Saag ,  Sam Possemiers ,  Pieter Van Den Abbeele ,  Tom Van De Wiele ,  Audrey Martine Neyrinck ,  Nathalie Maria Nelly Delzenne ,  Patrice D. Cani

发明人： Peter Frank Ekhart ,  Hans Van De Saag ,  Sam Possemiers ,  Pieter Van Den Abbeele ,  Tom Van De Wiele ,  Audrey Martine Neyrinck ,  Nathalie Maria Nelly Delzenne ,  Patrice D. Cani

IPC分类号： A61K38/16 ,  A61P1/00 ,  A61P37/00 ,  A61P9/00 ,  A61P3/04 ,  A61K35/74 ,  A61P3/00

CPC分类号： A61K31/7034 ,  A21D2/181 ,  A23L33/135 ,  A23L33/22 ,  A23L33/40 ,  A23V2002/00 ,  A61K8/73 ,  A61K31/715 ,  A61Q19/00 ,  C08B37/0057 ,  C08L5/00 ,  A23V2250/502 ,  A23V2250/5028 ,  A23V2200/3202

摘要： The present invention is directed to a particular arabinoxylan (“AX”) preparation and the finding that this preparation has a beneficial effect on the organization of the intestinal microbial community in the lumen and in particular at the site of the gut mucosa, where it modulates the barrier function of the intestinal surface, primarily by modulating the mucosa-associated microbial community towards a relative increase of health beneficial bacteria, such as bifidobacteria and lactobacilli. It is accordingly a first aspect of the present invention to provide said arabinoxylan preparation characterized in comprising isolated water-soluble arabinoxylans and the use thereof to improve functioning (e.g. barrier function) of the intestinal epithelium. Thus, in a further aspect the present invention provides compositions, both pharmaceutical and nutritional compositions, comprising said arabinoxylan preparations; in particular pharmaceuticals, medical foods, food supplements or food compositions, such as infant formula products, dairy products, bakery products or pastry products. The compositions optionally comprise probiotics such as Bifidobacterium or Lactobacillus.

摘要翻译： 本发明涉及特定的阿拉伯木聚糖（“AX”）制剂，并且发现该制剂对肠腔中尤其是在肠粘膜部位的肠微生物群落的组织具有有益作用，其中它调节 肠表面的屏障功能，主要是通过调节粘膜相关的微生物群落相对增加健康益菌，如双歧杆菌和乳杆菌。 因此，本发明的第一方面是提供所述阿拉伯木聚糖制剂，其特征在于包含分离的水溶性阿拉伯木聚糖及其用于改善肠上皮的功能（例如屏障功能）的用途。 因此，在另一方面，本发明提供了包含所述阿拉伯木聚糖制剂的组合物，包括药物和营养组合物; 特别是药物，医疗食品，食品添加剂或食品组合物，例如婴儿配方食品，乳制品，面包店产品或糕点产品。 组合物任选地包含益生菌如双歧杆菌或乳杆菌。