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公开(公告)号:US07303752B2
公开(公告)日:2007-12-04
申请号:US10825692
申请日:2004-04-16
申请人: Peter Hotez , James Ashcom , Mahnaz Bdamchian , Bin Zhan , Yan Wang , John Hawdon , Alexander Loukas , Angela Williamson , Brian Jones , Jeffrey Bethony , Gaddam Goud , Maria Elena Bottazzi , Susana Mendez
发明人: Peter Hotez , James Ashcom , Mahnaz Bdamchian , Bin Zhan , Yan Wang , John Hawdon , Alexander Loukas , Angela Williamson , Brian Jones , Jeffrey Bethony , Gaddam Goud , Maria Elena Bottazzi , Susana Mendez
IPC分类号: A61K39/00 , A61K39/002
CPC分类号: A61K39/0003 , A61K2039/55577 , Y02A50/412 , Y02A50/466
摘要: Preparations which elicit an immune response to hookworm antigens and which may be utilized as hookworm vaccines are provided. In addition, a method of increasing the effectiveness of vaccinations against infectious diseases in patients infected with hookworm is provided. The method involves chemically treating the hookworm infestation prior to administering the vaccine.
摘要翻译: 提供了引起钩虫抗原免疫应答并可用作钩虫疫苗的制剂。 另外,提供了一种增加感染钩虫感染病毒感染性疾病疫苗接种有效性的方法。 该方法包括在施用疫苗之前化学处理钩虫感染。
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公开(公告)号:US20050042232A1
公开(公告)日:2005-02-24
申请号:US10825692
申请日:2004-04-16
申请人: Peter Hotez , James Ashcom , Mahnaz Bdamchian , Bin Zhan , Yan Wang , John Hawdon , Alexander Loukas , Angela Williamson , Brian Jones , Jeffrey Bethony , Gaddam Goud , Maria Bottazzi , Susana Mendez
发明人: Peter Hotez , James Ashcom , Mahnaz Bdamchian , Bin Zhan , Yan Wang , John Hawdon , Alexander Loukas , Angela Williamson , Brian Jones , Jeffrey Bethony , Gaddam Goud , Maria Bottazzi , Susana Mendez
IPC分类号: A61K39/00 , A61K39/002
CPC分类号: A61K39/0003 , A61K2039/55577 , Y02A50/412 , Y02A50/466
摘要: Preparations which elicit an immune response to hookworm antigens and which may be utilized as hookworm vaccines are provided. In addition, a method of increasing the effectiveness of vaccinations against infectious diseases in patients infected with hookworm is provided. The method involves chemically treating the hookworm infestation prior to administering the vaccine.
摘要翻译: 提供了引起钩虫抗原免疫应答并可用作钩虫疫苗的制剂。 另外,提供了一种增加感染钩虫感染病毒感染性疾病疫苗接种有效性的方法。 该方法包括在施用疫苗之前化学处理钩虫感染。
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公开(公告)号:US20110200640A1
公开(公告)日:2011-08-18
申请号:US12999132
申请日:2009-06-30
申请人: Peter Hotez , Alexander Loukas , Mark Pearson , Jeffrey Bethony , Bin Zhan , Gaddam Goud , Maria Elena Bottazzi , David Diemert , Ami Shah Brown , Peter Giacomantonio
发明人: Peter Hotez , Alexander Loukas , Mark Pearson , Jeffrey Bethony , Bin Zhan , Gaddam Goud , Maria Elena Bottazzi , David Diemert , Ami Shah Brown , Peter Giacomantonio
IPC分类号: A61K39/002
CPC分类号: A61K39/0003 , A61K2039/55505 , A61K2039/55561 , Y02A50/423
摘要: A multivalent anthelmintic vaccine targets both hookworm and schistosomiasis. The vaccine includes, at a minimum, a recombinant third-stage larval hookworm antigen, a recombinant adult stage hookworm antigen, and a recombinant schistosome antigen. Preferably, the hookworm antigens are Necator americanus antigens, although antigens from other hookworm species (e.g. Ancylostoma duodenale) may also be employed. The schistosome antigen is preferably a Schistosoma mansoni or a Schistosoma haematobium antigen although antigens from other schistosome species (e.g. Schistosoma japonicum) may also be employed. In some cases full or partial sequences of schistosome antigens may be fused with full or partial sequences of hookworm {Necator americanus) to produce recombinant chimeric antigens.
摘要翻译: 一种多价驱虫肠炎疫苗靶向钩虫和血吸虫病。 该疫苗至少包含重组的第三代幼虫钩虫抗原,重组成虫阶段的钩虫抗原和重组血吸虫抗原。 优选地,钩虫抗原是美洲N虫抗原,尽管也可以使用来自其它钩虫属(例如十二指肠十二指肠)的抗原。 尽管也可以使用来自其它血吸虫物种(例如日本血吸虫)的抗原,血吸虫抗原优选为血吸虫血吸虫血吸虫血吸虫抗原。 在一些情况下,血吸虫抗原的全部或部分序列可以与钩虫(美洲{虫)的全部或部分序列融合以产生重组嵌合抗原。
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公开(公告)号:US08444994B2
公开(公告)日:2013-05-21
申请号:US12999132
申请日:2009-06-30
申请人: Peter Hotez , Alexander Loukas , Mark Pearson , Jeffrey Bethony , Bin Zhan , Gaddam Goud , Maria Elena Bottazzi , David Diemert , Ami Shah Brown , Peter Giacomautonio
发明人: Peter Hotez , Alexander Loukas , Mark Pearson , Jeffrey Bethony , Bin Zhan , Gaddam Goud , Maria Elena Bottazzi , David Diemert , Ami Shah Brown , Peter Giacomautonio
IPC分类号: A61K39/00 , A61K39/002 , A61K45/00 , A61K47/00
CPC分类号: A61K39/0003 , A61K2039/55505 , A61K2039/55561 , Y02A50/423
摘要: A multivalent anthelmintic vaccine targets both hookworm and schistosomiasis. The vaccine includes, at a minimum, a recombinant third-stage larval hookworm antigen, a recombinant adult stage hookworm antigen, and a recombinant schistosome antigen. Preferably, the hookworm antigens are Necator americanus antigens, although antigens from other hookworm species (e.g. Ancylostoma duodenale) may also be employed. The schistosome antigen is preferably a Schistosoma mansoni or a Schistosoma haematobium antigen although antigens from other schistosome species (e.g. Schistosoma japonicum) may also be employed. In some cases full or partial sequences of schistosome antigens may be fused with full or partial sequences of hookworm {Necator americanus) to produce recombinant chimeric antigens.
摘要翻译: 一种多价驱虫肠炎疫苗靶向钩虫和血吸虫病。 该疫苗至少包含重组的第三代幼虫钩虫抗原,重组成虫阶段的钩虫抗原和重组血吸虫抗原。 优选地,钩虫抗原是美洲N虫抗原,尽管也可以使用来自其它钩虫属(例如十二指肠十二指肠)的抗原。 尽管也可以使用来自其它血吸虫物种(例如日本血吸虫)的抗原,血吸虫抗原优选为血吸虫血吸虫血吸虫血吸虫抗原。 在一些情况下,血吸虫抗原的全部或部分序列可以与钩虫(美洲{虫)的全部或部分序列融合以产生重组嵌合抗原。
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公开(公告)号:US20080166377A1
公开(公告)日:2008-07-10
申请号:US11863912
申请日:2007-09-28
申请人: Peter Hotez , Alexander Loukas , Bin Zhan , Gaddam Goud , Jeffrey Bethony , Maria Elena Bottazzi , Aaron Miles
发明人: Peter Hotez , Alexander Loukas , Bin Zhan , Gaddam Goud , Jeffrey Bethony , Maria Elena Bottazzi , Aaron Miles
CPC分类号: A61K39/0003 , A61K2039/55505 , A61K2039/55561 , A61K2039/55572
摘要: A vaccine for human hookworm is provided. The vaccine comprises at least one L3 larval stage antigen (e.g. Na-ASP-2 or Na-SAA-2) and at least one adult stage human hookworm antigen (e.g. Na-APR-1, Na-CP-2, Na-CP-3, Na-CP-4, Na-CP-5, or Na-GST-1) and adjuvants.
摘要翻译: 提供人类钩虫疫苗。 该疫苗包含至少一种L3幼虫期抗原(例如Na-ASP-2或Na-SAA-2)和至少一种成虫阶段人钩虫抗原(例如Na-APR-1,Na-CP-2,Na-CP -3,Na-CP-4,Na-CP-5或Na-GST-1)和佐剂。
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公开(公告)号:US08211438B2
公开(公告)日:2012-07-03
申请号:US12492734
申请日:2009-06-26
申请人: Peter Hotez , Alexander Loukas , Bin Zhan , Gaddam Goud , Jeffrey Bethony , Maria Elena Bottazzi , Aaron Miles
发明人: Peter Hotez , Alexander Loukas , Bin Zhan , Gaddam Goud , Jeffrey Bethony , Maria Elena Bottazzi , Aaron Miles
IPC分类号: A61K39/00 , A61K39/002
CPC分类号: A61K39/0003 , A61K2039/55505 , A61K2039/55561 , A61K2039/55572
摘要: A vaccine for human hookworm is provided. The vaccine comprises at least one L3 larval stage antigen (e.g. Na-ASP-2 or Na-SAA-2) and at least one adult stage human hookworm antigen (e.g. Na-APR-1, Na-CP-2, Na-CP-3, Na-CP-4, Na-CP-5, or Na-GST-1) and adjuvants.
摘要翻译: 提供人类钩虫疫苗。 疫苗包含至少一种L3幼虫期抗原(例如Na-ASP-2或Na-SAA-2)和至少一种成虫阶段人钩虫抗原(例如Na-APR-1,Na-CP-2,Na-CP -3,Na-CP-4,Na-CP-5或Na-GST-1)和佐剂。
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公开(公告)号:US20100003285A1
公开(公告)日:2010-01-07
申请号:US12492734
申请日:2009-06-26
申请人: Peter Hotez , Alexander Loukas , Bin Zhan , Gaddam Goud , Jeffrey Bethony , Maria Elena Bottazzi , Aaron Miles
发明人: Peter Hotez , Alexander Loukas , Bin Zhan , Gaddam Goud , Jeffrey Bethony , Maria Elena Bottazzi , Aaron Miles
CPC分类号: A61K39/0003 , A61K2039/55505 , A61K2039/55561 , A61K2039/55572
摘要: A vaccine for human hookworm is provided. The vaccine comprises at least one L3 larval stage antigen (e.g. Na-ASP-2 or Na-SAA-2) and at least one adult stage human hookworm antigen (e.g. Na-APR-1, Na-CP-2, Na-CP-3, Na-CP-4, Na-CP-5, or Na-GST-1) and adjuvants.
摘要翻译: 提供人类钩虫疫苗。 该疫苗包含至少一种L3幼虫期抗原(例如Na-ASP-2或Na-SAA-2)和至少一种成虫阶段人钩虫抗原(例如Na-APR-1,Na-CP-2,Na-CP -3,Na-CP-4,Na-CP-5或Na-GST-1)和佐剂。
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