公开(公告)号：US09637500B2

公开(公告)日：2017-05-02

申请号：US14898582

申请日：2014-06-17

Applicant: Pfizer Inc.

Inventor： Andrew James Jensen ,  Suman Luthra ,  Paul Francis Richardson

IPC: C07D213/65 ,  A61K31/4439 ,  C07D498/18

CPC classification number: C07D498/18

Abstract: This invention relates to crystalline solvates of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benz- oxadiazacyclotetradecine-3-carbonitrile, useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to pharmaceutical compositions comprising such crystalline solvates, and to methods of using such solvates and compositions in the treatment of abnormal cell growth in mammals, especially humans.