公开(公告)号：US20160368919A1

公开(公告)日：2016-12-22

申请号：US15184097

申请日：2016-06-16

Applicant: Pfizer Inc.

Inventor： Agustin Casimiro-Garcia ,  Bruce Allen Lefker ,  Nikolaos Papaioannou ,  Arjun Venkat Narayanan ,  Jotham Wadsworth Coe

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: Disclosed are novel pyridine pyrazinones or pharmaceutically acceptable salts thereof. Pharmaceutical compositions and the use of the compounds to treat diseases or disorders that are BET family bromodomain-dependent are also disclosed. Methods for preparing and using these compounds are further described.

Abstract translation: 公开了新的吡啶吡嗪酮或其药学上可接受的盐。 还公开了药物组合物和化合物用于治疗作为BET家族溴结构域依赖性的疾病或病症的用途。 进一步描述制备和使用这些化合物的方法。